653233

2,4-Dichloro-5-fluoropyrimidine

97%

• Formule empirique (notation de Hill) : C₄HCl₂FN₂
• Numéro CAS: 2927-71-1
• Poids moléculaire : 166.97
• NACRES: NA.22
• PubChem Substance ID: 24883938
• UNSPSC Code: 12352100
• MDL number: MFCD00233551
• Assay: 97%
• Form: solid

Propriétés

• Quality Segment: 100
• assay: 97%
• form: solid
• mp: 37-41 °C (lit.)
• functional group: chloro, fluoro
• SMILES string: Fc1cnc(Cl)nc1Cl
• InChI: 1S/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H
• InChI key: WHPFEQUEHBULBW-UHFFFAOYSA-N

Description

Application

2,4-Dichloro-5-fluoropyrimidine can be used as a starting material to synthesize:

• 5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides as potential kinase inhibitors.
• A series of 2,4-diamino-5-fluoropyrimidine derivatives as potential protein kinase Cθ inhibitors.
• 2,4-Bisanilinopyrimidine derivatives as potential aurora kinases inhibitors.
• 5-fluoro-N,N-bis(4-methoxyphenyl)-2,4-pyrimidinediamine by reacting with p-methoxy aniline in the presence of DIPEA.
• 2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine by Suzuki coupling reaction in the presence of (4-fluorophenyl)boronic acid triphenylphosphine, and palladium(II) acetate catalyst.
• 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a scaffold, which is used in the preparation of potent deoxycytidine kinase inhibitors.

Informations sur la sécurité

• Pictogrammes: GHS05,GHS07
• Mot-clé: Danger
• Codes de danger: H302,H314,H317
• Mentions de précaution: P260 - P272 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1A
• Classe de stockage: 8A - Combustible corrosive hazardous materials
• Point d'éclair (°F): 222.8 °F - closed cup
• Point d'éclair (°C): 106 °C - closed cup
• EPI (équipement de protection individuelle): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges