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Principaux documents

145904

Sigma-Aldrich

Quinine

90%

Synonyme(s) :

6′-Methoxycinchonidine

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About This Item

Formule empirique (notation de Hill) :
C20H24N2O2
Numéro CAS:
Poids moléculaire :
324.42
Beilstein:
91867
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352104
ID de substance PubChem :
Nomenclature NACRES :
NA.22
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Niveau de qualité

Essai

90%

Activité optique

[α]25/D −165°, c = 2 in ethanol

Pf

173-175 °C (lit.)

Groupe fonctionnel

hydroxyl

Chaîne SMILES 

COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1

InChI

1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1

Clé InChI

LOUPRKONTZGTKE-WZBLMQSHSA-N

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Description générale

Quinine, a cinchona alkaloid found in the bark of the cinchona tree, is known for its anti-malarial property.[1]

Application

Quinine has been used as a standard during the chemical evaluation of alkaloids in the hydroethanolic extracts of endophytic fungi obtained from the leaves of Costus spiralis by TLC.[2]
Resolving agent for carboxylic acids.[3] Catalyzes the kinetic resolution of furanones.[4]

Actions biochimiques/physiologiques

Potassium channel blocker

Autres remarques

remainder hydroquinine

Pictogrammes

Exclamation mark

Mention d'avertissement

Warning

Mentions de danger

Classification des risques

Acute Tox. 4 Oral - Skin Sens. 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Certificats d'analyse (COA)

Lot/Batch Number

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Chirality, 4, 323-323 (1992)
Chemical assessment and antimicrobial and antioxidant activities of endophytic fungi extracts isolated from Costus spiralis (Jacq.) Roscoe (Costaceae)
Marson Ascencio PG, et al
Evidence-Based Complementary and Alternative Medicine : ECAM, 2014 (2014)
Tetrahedron, 50, 4775-4775 (1994)
Chris de Graaf et al.
Journal of medicinal chemistry, 49(8), 2417-2430 (2006-04-14)
Automated docking strategies successfully applied to binding mode predictions of ligands in Cyt P450 crystal structures in an earlier study (de Graaf et al. J. Med. Chem. 2005, 7, 2308-2318) were used for the catalytic site prediction (CSP) of 65
Harald Noedl et al.
Antimicrobial agents and chemotherapy, 51(2), 651-656 (2006-11-23)
Azithromycin when used in combination with faster-acting antimalarials has proven efficacious in treating Plasmodium falciparum malaria in phase 2 clinical trials. The aim of this study was to establish optimal combination ratios for azithromycin in combination with either dihydroartemisinin or

Questions

1–3 of 3 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. What is the Flinn compatibility storage code and the storage condition for product 145904?

    1 answer
    1. Product 145904 should be stored at ambient temperature in a dark place due to its light sensitivity. The Flinn compatibility storage code (TRGS 510) for this item is 11, indicating it is a combustible solid.

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