1288463

Gemcitabine hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): 2′-Deoxy-2′,2′-difluorocytidine; dFdC, Gemzar (Lilly), LY-188011, dFdC, dFdCyd
• Empirical Formula (Hill Notation): C₉H₁₁F₂N₃O₄ · HCl
• CAS Number: 122111-03-9
• Molecular Weight: 299.66
• NACRES: NA.24
• PubChem Substance ID: 329749929
• UNSPSC Code: 41116107
• MDL number: MFCD01735988

Properties

• grade: pharmaceutical primary standard
• agency: USP
• API family: gemcitabine
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule); pharmaceutical
• format: neat
• storage temp.: 2-8°C
• SMILES string: Cl.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)C2(F)F
• InChI: 1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1
• InChI key: OKKDEIYWILRZIA-OSZBKLCCSA-N
• Gene Information: human ... POLA1(5422), POLA2(23649), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558), RRM1(6240), RRM2(6241), RRM2B(50484) ;

Description

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the issuing Pharmacopoeia.

For further information and support please go to the website of the issuing Pharmacopoeia.

Application

It is intended to be used as a USP reference standard in specified quality tests and assays.
Also used to prepare standard solutions in the assay and impurities analysis using LC-UV as described in the following United States Pharmacopeia (USP) monographs:

• Gemcitabine Hydrochloride
• Gemcitabine for Injection
  

Biochem/physiol Actions

Gemcitabine is a widely used antineoplastic agent and antimetabolite.

Gemcitabine is a widely used antitumor agents in both clinics and research labs. It is an antineoplastic agent and antimetabolite.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Codes: H360
• Precautionary Statements: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable