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Key Documents

1173508

USP

Desoximetasone

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

9-Fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione

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About This Item

Empirical Formula (Hill Notation):
C22H29FO4
CAS Number:
Molecular Weight:
376.46
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24

Pricing and availability is not currently available.

biological source

synthetic

Agency

USP

vapor pressure

<0.0000001 kPa ( 25 °C)

API family

desoximetasone

form

powder

packaging

pkg of 200 mg

manufacturer/tradename

USP

storage condition

protect from light

color

white

solubility

acetone: freely soluble
alcohol: freely soluble
benzene: slightly soluble
chloroform: freely soluble
ether: slightly soluble
water: insoluble

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This Item
1176007Y0001177Y0001593
application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

form

powder

form

-

form

powder

form

powder

biological source

synthetic

biological source

synthetic

biological source

synthetic

biological source

synthetic

agency

USP

agency

USP

agency

EP

agency

EP

vapor pressure

<0.0000001 kPa ( 25 °C)

vapor pressure

<0.0000001 kPa ( 25 °C)

vapor pressure

-

vapor pressure

-

General description

Desoximetasone is a topical corticosteroid known to modify the functions of leukocytes that are mainly responsible for skin infections, inflammation and allergies.[1][2]

Application

Desoximetasone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Desoximetasone Cream
  • Desoximetasone Gel
  • Desoximetasone Ointment
  • Dexamethasone

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

related product

Pictograms

Health hazardExclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


  • Certificates of Analysis (COA)

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    Development and Validation of RP-HPLC Method for Desoximetasone in Bulk and Cream Formulation
    Gorle A, et al.
    Journal of Drug Delivery and Therapeutics, 9(3), 154-159 (2019)
    Topical corticosteroids: mechanisms of action.
    Kragballe, K
    Acta Dermato-Venereologica. Supplementum, 151(3), 7-7 (1989)
    S Vladimirov et al.
    Journal of pharmaceutical and biomedical analysis, 14(8-10), 947-950 (1996-06-01)
    The proposed method is based on coloured hydrazone formation with 1,4-dihydrazinophthalazine as a reagent. Heating at 85 degrees C for 2 h was found necessary to ensure optimal hydrazone formation in the presence of hydrochloric acid. The yellow hydrazone product
    Desoximetasone USP Monograph
    USP43-NF38: United States Pharmacopeia and National Formulary
    United States Pharmacopeia, 44(2), 1272-1272 (2020)

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