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Z687928

IdMOC® tissue culture plate

4 chambers, size 24 wells, pkg of 5 ea

Synonym(s):

in vitro cell culture plate, Multiple Organ Co-Culture, Integrated Descrete Multiple Organ Culture Plates

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About This Item

UNSPSC Code:
41122107
NACRES:
NB.22

Pricing and availability is not currently available.

material

clear polystyrene
clear wells

sterility

sterile

feature

lid

packaging

pkg of 5 ea

manufacturer/tradename

Advanced Pharmaceutical Sciences 71034

size

24 wells

working volume

300 μL

color

clear

suitability

suitable for (suitable for multiple organ co-culture)

binding type

Collagen I coated surface

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Show Differences

1 of 4

This Item
BR781910BR781911BR781913
material

flat bottom, white wells, polystyrene

material

flat bottom, polystyrene , white wells

material

black wells, flat bottom, polystyrene

material

black wells, flat bottom, polystyrene

sterility

sterile

sterility

sterile

sterility

sterile

sterility

sterile

feature

lid

feature

lid, skirt (F-bottom, transparent bottom)

feature

lid, skirt (F-bottom, transparent bottom)

feature

lid, skirt (F-bottom, transparent bottom)

packaging

pack of 5 ea

packaging

pack of 40 ea

packaging

pack of 40 ea

packaging

pack of 5 ea

manufacturer/tradename

BRAND 781912

manufacturer/tradename

BRAND 781910

manufacturer/tradename

BRAND 781911

manufacturer/tradename

BRAND 781913

General description

IdMOC plates are a novel In Vitro System for routine screening of ADMET drug properties.

In previous in vitro systems, each cell type was studied in isolation, ignoring critical interactions between organs when metabolizing drugs. This led to the possibility of many factors such as inter-organ toxicity going unrecognized in drug evaluations. The IdMOC models in vivo multiple-organ interaction, thus allowing the evaluation of organ-specific effects of a drug and its metabolites. The IdMOC consists of multiple, inner wells within a larger interconnecting chamber. Multiple cell types are first individually cultured in the inner wells in media optimized for each cell type.

On the day of experimentation, the individual media are removed and the chamber is filled with a single universal medium, flooding the inner wells and allowing well-to-well communication via the overlying medium. The test material is then added to the overlying medium. After experimentation, the overlying medium can be analyzed for overall metabolism of the test material, and individual cell types can be processed for the quantification of associated test material to evaluate possible organ-specific bioaccumulation, evaluation of cell viability for cytotoxicity, and efficacy.

Applications:
  • Efficacy: Evaluation of the desired on-target and off-target effects via the examination of pharmacological effects of a drug in cells from target organs as well as off-target organs
  • Drug distribution: Estimation of the potential differential drug distribution in multiple organs via the quantification of drugs in cells from multiple organs after exposure
  • Drug metabolism: Drug stability and metabolite formation after metabolism by cells from multiple organs
  • Drug toxicity: Simultaneous evaluation of toxic potential of a drug on cells from multiple organs under identical experimental conditions

Legal Information

IdMOC is a registered trademark of Advanced Pharmaceutical Sciences, Inc.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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