Y0503
Y-27632 dihydrochloride
≥98% (HPLC)
Synonym(s):
Rock inhibitor y-27632, Y-27632 2HCl, (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-Pyridyl)cyclohexanecarboxamide dihydrochloride
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About This Item
Recommended Products
biological source
synthetic (organic)
Quality Level
Assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +3.0 to +5.0°, c = 1.0 in methanol
color
white to beige
solubility
H2O: 14 mg/mL
storage temp.
2-8°C
SMILES string
Cl.Cl.C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc2ccncc2
InChI
1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11-,12-;;/m1../s1
General description
Application
- as a medium supplement in pancreatic ductal adenocarcinoma organoid culture[7]
- in the inhibition of Ras homolog gene family (Rho) kinase in mouse embryonic stem cells[8]
- in the inhibition of Rho-associated protein kinase (ROCK) in human embryonic stem cells[9] and human induced pluripotent stem cells (iPSCs)[10]
- Y-27632 dihydrochloride has been used as a supplement in the E8 medium to promote in vitro differentiation of human pluripotent stem cells[11]
Biochem/physiol Actions
Features and Benefits
Legal Information
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
Certificates of Analysis (COA)
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Articles
Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.
Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.
Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.
Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.
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