Tau (τ), also known as MAPT (microtubule associated protein tau) is encoded by the gene mapped on human chromosome 17q21.3. It is highly expressed in neurons but is most prominent in axons.
Immunogen
chemically synthesized phosphopeptide derived from the region of human tau that contains serine262.
Biochem/physiol Actions
Removal of Tau (τ) results in developmental delay and learning disability. It participates in the pathology of Alzheimer′s disease (AD). Tau helps in the assembly and maintenance of microtubule structure. Measurement of phosphorylated tau (P-tau) levels in cerebrospinal fluid (CSF) acts a potential marker for differentiation between AD and dementia with Lewy bodies (DLB).
Physical form
Supplied in 100 μL of Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 50% glycerol, 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide.
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CSF phosphorylated tau is a possible marker for discriminating Alzheimer's disease from dementia with Lewy bodies
Parnetti L
Neurological Sciences, 22, 77-78 (2001)
Microdeletion encompassing MAPT at chromosome 17q21.3 is associated with developmental delay and learning disability.
Shaw-Smith C
Nature Genetics, 38, 1032-1037 (2006)
Linkage Disequilibrium and Association of MAPT H1 in Parkinson Disease
Skipper L
American Journal of Human Genetics, 2004, 669-677 (2004)
The H1c haplotype at the MAPT locus is associated with Alzheimer's disease
Myers AJ
Human Molecular Genetics, 14, 2399-2404 (2005)
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