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SML3773

Sigma-Aldrich

PITCOIN1

≥98% (HPLC)

Synonym(s):

2-((4-Oxo-3-phenethyl-3,4-dihydropteridin-2-yl)thio)-N-(thiazol-2-yl)acetamide, 2-[[3,4-Dihydro-4-oxo-3-(2-phenylethyl)-2-pteridinyl]thio]-N-2-thiazolylacetamide

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About This Item

Empirical Formula (Hill Notation):
C19H16N6O2S2
CAS Number:
Molecular Weight:
424.50
UNSPSC Code:
12352200
NACRES:
NA.21

Pricing and availability is not currently available.

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

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SYNF100002SYNF100003ASYNF100001
packaging

pkg of 1 ea

packaging

pkg of 1 ea

packaging

pkg of 1 ea

packaging

pkg of 1 ea

capacity

1000 mL

capacity

-

capacity

-

capacity

-

Biochem/physiol Actions

PITCOIN1 is a cell permeable, potent, and highly selective inhibitor of Phosphatidylinositol 3-kinase type 2α (PI3KC2α) catalytic activity. Also, PITCOIN1 is a moderate inhibitor of PI3KC2γ and PI3KC2β. PITCOIN1 inhibits PI3KC2α-mediated synthesis of PI(3,4)P2 and PI(3)P. It exhibits potent antithrombotic activity by counteracting platelet membrane remodeling.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Development of selective inhibitors of phosphatidylinositol 3-kinase C2?
Nature Chemical Biology, 19(1), 18-27 (2023)

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