SML2087

SJ000291942

≥98% (HPLC)

• Synonym(s): 2-(4-Ethylphenoxy)-N-(4-fluoro-3-nitrophenyl)-acetamide
• Empirical Formula (Hill Notation): C₁₆H₁₅FN₂O₄
• CAS Number: 425613-09-8
• Molecular Weight: 318.30
• MDL number: MFCD02219567
• UNSPSC Code: 12352202
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CCC1=CC=C(OCC(NC2=CC([N+]([O-])=O)=C(F)C=C2)=O)C=C1
• InChI: 1S/C16H15FN2O4/c1-2-11-3-6-13(7-4-11)23-10-16(20)18-12-5-8-14(17)15(9-12)19(21)22/h3-9H,2,10H2,1H3,(H,18,20)
• InChI key: YSZJLXPXVFGTNK-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Activator of Bone Morphogenetic Protein (BMP) signaling

SJ000291942 is an activator of Bone Morphogenetic Protein (BMP) signaling with an EC50 value < 1 μM. Bone Morphogenetic Proteins (BMPs) are a group of growth factors and cytokines were originally discovered by their ability to induce the formation of bone and cartilage, but are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. SJ000291942 was shown to ventralize zebrafish embryos, activate SMAD1/5/8 phosphorylation, and induce the differentiation of C2C12 myoblasts to osteoblasts in manner consistent with BMP4 activation.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3