SML1267

Bryostatin 3

≥95% (HPLC)

• Synonym(s): [4S-[4R*(2E,4E),5R*,7E,9S*,11Z,13R*,15R*,17R*,19S*,21S*,25S*(S*),27S*,27aR*]]-2,4-Octadienoic acid,17-(acetyloxy)-4,5,6,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,25,26,27,27a-docosahydro-5,15,21-trihydroxy-25-(1-hydroxyethyl)-11-(2-methoxy-2-oxoethylidene)-6,6,16,16-tetramethyl-2,23-dioxo-5,27:9,13:15,19-triepoxy-2H-furo[2,3-e]oxacyclohexacosin-4-yl ester
• Empirical Formula (Hill Notation): C₄₆H₆₄O₁₇
• CAS Number: 143370-84-7
• Molecular Weight: 888.99
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• biological source: Bugula neritina (sponge)
• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: film
• color: colorless to light yellow
• shipped in: wet ice
• storage temp.: −20°C
• InChI: 1S/C46H64O17/c1-9-10-11-12-13-14-37(50)61-42-33-23-40(53)60-41(33)35-24-34(26(2)47)59-39(52)21-29(49)20-31-22-36(57-27(3)48)44(6,7)45(54,62-31)25-32-18-28(19-38(51)56-8)17-30(58-32)15-16-43(4,5)46(42,55)63-35/h11-16,19,23,26,29-32,34-36,41-42,47,49,54-55H,9-10,17-18,20-22,24-25H2,1-8H3/b12-11+,14-13+,16-15-,28-19+/t26-,29-,30+,31-,32+,34-,35-,36+,41+,42+,45+,46-/m1/s1
• InChI key: BSNHYLUEHJOXFN-UUIHWDITSA-N

Description

Biochem/physiol Actions

Bryostatin 3 is a potent protein kinase C activator with a Ki of 2.75 nM, and an antagonist to phorbol ester tumor promoter TPA. Bryostatin 3 is isolated from the bryozoan Bugula neritina.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable