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Merck

SML1241

Sigma-Aldrich

Pyr6

≥98% (HPLC)

Synonym(s):

N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide

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About This Item

Empirical Formula (Hill Notation):
C17H9F7N4O
CAS Number:
Molecular Weight:
418.27
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Pricing and availability is not currently available.

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=CC=NC=C1F)NC2=CC=C(N3C(C(F)(F)F)=CC(C(F)(F)F)=N3)C=C2

InChI

1S/C17H9F7N4O/c18-12-8-25-6-5-11(12)15(29)26-9-1-3-10(4-2-9)28-14(17(22,23)24)7-13(27-28)16(19,20)21/h1-8H,(H,26,29)

InChI key

XZIQSOZOLJJMFN-UHFFFAOYSA-N

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1 of 4

This Item
81831A29585337528
storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

refractive index

n20/D 1.494

refractive index

-

refractive index

n20/D 1.469 (lit.)

refractive index

n20/D 1.469 (lit.)

density

1.335 g/mL at 25 °C

density

1.39 g/mL at 20 °C

density

1.398 g/mL at 25 °C (lit.)

density

1.398 g/mL at 25 °C (lit.)

bp

88-90 °C

bp

-

bp

70-71 °C (lit.)

bp

70-71 °C (lit.)

contains

0.3% magnesium oxide as stabilizer

contains

~0.3% magnesium oxide light as stabilizer

contains

≤1000 ppm propylene oxide as stabilizer

contains

≤1000 ppm propylene oxide as stabilizer

Biochem/physiol Actions

Pyr6 is a selective inhibitor of calcium release from the endoplasmic reticulum via STIM1/Orai1 mediated, store operated calcium entry (SOCE). Pyr6 blocks SOCE in thapsigargin treated, calcium depleted BRL-2H3 cells (IC50 = 0.49 μM), but has poor activity against carbachol-induced, TRPC3-mediated calcium entry in TRPC3-transfected HEK293 cells (IC50 = 18.46 μM).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Samuel Shin et al.
Cellular signalling, 67, 109484-109484 (2019-11-27)
Oxidative stress and reactive oxygen species (ROS) generation can be influenced by G-protein coupled receptor (GPCR)-mediated regulation of intracellular Ca2+ ([Ca2+]i) signaling. ROS production are much higher in proximal tubular (PT) cells; in addition, the lack of antioxidants enhances the
Prabir K Chakraborty et al.
Nature communications, 8, 14634-14634 (2017-05-23)
Cancer cells actively promote aerobic glycolysis to sustain their metabolic requirements through mechanisms not always clear. Here, we demonstrate that the gatekeeper of mitochondrial Ca

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