Skip to Content
Merck
All Photos(3)

Key Documents

SAB4501301

Sigma-Aldrich

Anti-NMDAR1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

GLURZ1, GRIN1, Glutamate [NMDA] receptor subunit ζ 1 precursor, N-methyl-D-aspartate receptor, NMD-R1

Sign Into View Organizational & Contract Pricing


About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Pricing and availability is not currently available.

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 105 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
748684324566242306
Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

−20°C

form

solution

form

liquid

form

-

form

liquid

concentration

~20% in toluene

concentration

15 wt. % in toluene

concentration

2.0 M in THF

concentration

-

impurities

≤300 mg/kg benzene

impurities

-

impurities

-

impurities

-

General description

N-methyl-d-aspartate receptor (NMDAR1) is a subtype of the ionotropic glutamate receptors (iGluRs). It is coded by GRIN1 gene. It is located on human chromosome 9q34.3. NMDAR1is expressed in epidermal melanocytes.
Anti-NMDAR1 antibody detects endogenous levels of total NMDAR1 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human NMDAR1.

Immunogen Range: 856-905

Application

Anti-NMDAR1, C-Terminal antibody has been used in western blot analysis.

Biochem/physiol Actions

N-methyl-d-aspartate receptor (NMDAR1) plays an important role in the pathophysiology of schizophrenia, bipolar disorder and depression. Mutations in GRIN1 gene results in severe intellectual disability, hypotonia, hyperkinetic and stereotyped movements, and epilepsy.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


  • Certificates of Analysis (COA)

    Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

    Need A Sample COA?

    This is a sample Certificate of Analysis (COA) and may not represent a recently manufactured lot of this specific product.

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    De novo GRIN1 mutations: An emerging cause of severe early infantile encephalopathy
    Zehavi Y, et al.
    European Journal of Medical Genetics, 60(6), 317-320 (2017)
    Evidence that the N-methyl-D-aspartate subunit 1 receptor gene (GRIN1) confers susceptibility to bipolar disorder
    Mundo E, et al.
    Molecular Psychiatry, 8(2), 241-241 (2003)
    The activation of N-methyl-d-aspartate receptors downregulates transient outward potassium and L-type calcium currents in rat models of depression
    Liu X, et al.
    American Journal of Physiology. Cell Physiology, 313(2), C187-C196 (2017)
    Xin Liu et al.
    American journal of physiology. Cell physiology, 313(2), C187-C196 (2017-06-02)
    Major depression is an important clinical factor in ventricular arrhythmia. Patients diagnosed with major depression overexpress N-methyl-d-aspartate receptors (NMDARs). Previous studies found that chronic NMDAR activation increases susceptibility to ventricular arrhythmias. We aimed to explore the mechanisms by which NMDAR
    The effect of the NMDA receptor-dependent signaling pathway on cell morphology and melanosome transfer in melanocytes
    Ni J, et al.
    Journal of Dermatological Science, 84(3), 296-304 (2016)

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service