Anti-Claudin 7 Antibody detects endogenous levels of total Claudin 7 protein.
Claudin 7 is a tight junction membrane protein that belongs to claudins (cld) family. It is upregulated at high level in the upper gastrointestinal tract and the liver. It is located on human chromosome 17p13.
Immunogen
The antiserum was produced against synthesized peptide derived from human Claudin 7.
Immunogen Range: 162-211
Biochem/physiol Actions
In HCC827 and NCI-H358 lung cancer cells, suppression of claudin-7 decreases the expression of integrin β1. Claudins are important constituents of tight junctions (TJ) in the upper region of epithelial cells.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Tissue engineering. Part A, 26(19-20), 1091-1098 (2020-04-22)
Patient-oriented applications of cell culture include cell therapy of organ failure like chronic renal failure. Clinical deployment of a cell-based device for artificial renal replacement requires qualitative and quantitative fidelity of a cultured cell to its in vivo counterpart. Active
The claudins
Lal-Nag M and Morin P J
Genome Biology (2009)
A non-tight junction function of claudin-7-Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment
Lu Z, et al.
Molecular Cancer (2015)
The importance of claudin-7 palmitoylation on membrane subdomain localization and metastasis-promoting activities
Development (Cambridge, England), 144(22), 4148-4158 (2017-10-11)
Kidney collecting system development requires integrin-dependent cell-extracellular matrix interactions. Integrins are heterodimeric transmembrane receptors consisting of α and β subunits; crucial integrins in the kidney collecting system express the β1 subunit. The β1 cytoplasmic tail has two NPxY motifs that
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