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Key Documents

PZ0042

Sigma-Aldrich

Sulopenem

≥97% (HPLC)

Synonym(s):

(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[[(1R,3S)-tetrahydro-1-oxido-3-thienyl]thio]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, CP-70429

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About This Item

Empirical Formula (Hill Notation):
C12H15NO5S3
CAS Number:
Molecular Weight:
349.45
UNSPSC Code:
51111800
NACRES:
NA.77

Pricing and availability is not currently available.

Assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=C(O)C1=C(S[C@@H]2C[S@+]([O-])CC2)S[C@@]3([H])N1C([C@]3([H])[C@H](O)C)=O

InChI

1S/C12H15NO5S3/c1-5(14)7-9(15)13-8(11(16)17)12(20-10(7)13)19-6-2-3-21(18)4-6/h5-7,10,14H,2-4H2,1H3,(H,16,17)/t5-,6?,7+,10-,21?/m1/s1

InChI key

FLSUCZWOEMTFAQ-JNCILSLHSA-N

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This Item
PZ038SML2846SML2859
Sulopenem ≥97% (HPLC)

PZ0042

Sulopenem

AB-1 ≥98% (HPLC)

SML2859

AB-1

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

storage temp.

−20°C

storage temp.

room temp

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

shipped in

dry ice

shipped in

-

shipped in

-

shipped in

-

Biochem/physiol Actions

Sulopenem is an orally available penem antibiotic designed to treat Gram-negative multi-drug resistant infections. It can be administered as an intravenous preparation, and it is also orally available.
Sulopenem, formerly CP-70,429, is stable to renal dehydropeptidase I and hydrolytic activity of AmpC β-lactamases and extended-spectrum β-lactamases (ESBLs) that convey resistance to third-generation cephalosporins. This action of sulopenem helps to act against urgent drug-resistant antimicrobial threats, including ESBL-producing Enterobacteriaceae.[1] Sulopenem is effective than ciprofloxacin for treating urogenital upper urinary tract infection (uUTI) in adult women due to quinolone non-susceptible pathogens.[2]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


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    LB-1. Efficacy and Safety of Oral Sulopenem Etzadroxil/Probenecid Versus Oral Ciprofloxacin in the Treatment of Uncomplicated Urinary Tract Infections (uUTI) in Adult Women: Results from the SURE-1 Trial
    Open forum infectious diseases, 7(Suppl 1) , S844-S844 (2020)
    James A Karlowsky et al.
    Antimicrobial agents and chemotherapy, 63(1) (2018-11-07)
    The in vitro activity of sulopenem was assessed against a collection from 2014 to 2016 of 539 urinary isolates of Escherichia coli from Canadian patients by using CLSI-defined broth microdilution methodology. A concentration of sulopenem 0.03 µg/ml inhibited both 50% (MIC50)
    Simi S Paknikar et al.
    North American journal of medical sciences, 4(11), 537-547 (2012-11-28)
    In order to deal with the rising problem of antibiotic resistance, newer antibacterials are being discovered and added to existing pool. Since the year 2000, however, only four new classes of antibacterials have been discovered. These include the oxazolidinones, glycolipopeptides
    Klaudia Kosowska-Shick et al.
    Antimicrobial agents and chemotherapy, 53(6), 2239-2247 (2009-03-25)
    For 297 penicillin-susceptible, -intermediate, and -resistant pneumococcal strains, the sulopenem MIC(50)s were 0.008, 0.06, and 0.25, respectively, and the sulopenem MIC(90)s were 0.016, 0.25, and 0.5 microg/ml, respectively. The MIC(50)s of amoxicillin for the corresponding strains were 0.03, 0.25, and

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