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P2534

Sigma-Aldrich

Poly-L-histidine hydrochloride

mol wt ≥5000

Synonym(s):

L-Histidine homopolymer hydrochloride

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About This Item

CAS Number:
61857-39-4
MDL number:
MFCD00166382
UNSPSC Code:
12352209
PubChem Substance ID:
24898335
NACRES:
NA.26

form

powder

Quality Level

200

mol wt

≥5000

color

white to very light yellow

storage temp.

−20°C

SMILES string

N[C@H](Cc1c[nH]cn1)C(O)=O

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Analysis Note

Molecular weight by MALLS.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Carboxymethyl poly(L-histidine) as a new pH-sensitive polypeptide to enhance polyplex gene delivery.
Asayama S, Sudo M, et al.
Molecular Pharmacology, 5, 898-901 (2008)
Pablo R Dalmasso et al.
Analytica chimica acta, 710, 58-64 (2011-11-30)
We report for the first time the use of polyhistidine (Polyhis) to efficiently disperse multiwall carbon nanotubes (MWCNTs). The optimum dispersion MWCNT-Polyhis was obtained by sonicating for 30 min 1.0 mg mL(-1) MWCNTs in 0.25 mg mL(-1) Polyhis solution prepared
J M Benns et al.
Bioconjugate chemistry, 11(5), 637-645 (2000-09-20)
Advancing biotechnology spurs the development of new pharmaceutically engineered gene delivery vehicles. Poly(L-histidine) ¿PLH¿ has been shown to induce membrane fusion at endosomal pH values, whereas PLL has a well documented efficacy in polyplex formation. Therefore, N-Ac-poly(L-histidine)-graft-poly(L-lysine) ¿PLH-g-PLL¿ was synthesized

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Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

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