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N0758

Sigma-Aldrich

Naphthol AS-D chloroacetate

esterase substrate, fluorogenic, ≥98% (TLC), powder

Synonym(s):

3-Hydroxy-2-naphthoic-o-toluidide chloroacetate

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About This Item

Empirical Formula (Hill Notation):
C20H16ClNO3
CAS Number:
35245-26-2
Molecular Weight:
353.80
EC Number:
252-463-5
MDL number:
MFCD00042714
UNSPSC Code:
12352204
PubChem Substance ID:
24897441
NACRES:
NA.83

product name

Naphthol AS-D chloroacetate, esterase substrate

Quality Level

200

Assay

≥98% (TLC)

form

powder

solubility

acetone: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Cc1ccccc1NC(=O)c2cc3ccccc3cc2OC(=O)CCl

InChI

1S/C20H16ClNO3/c1-13-6-2-5-9-17(13)22-20(24)16-10-14-7-3-4-8-15(14)11-18(16)25-19(23)12-21/h2-11H,12H2,1H3,(H,22,24)

InChI key

FMVKYSCWHDVMGO-UHFFFAOYSA-N

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Application

Naphthol AS-D chloroacetate has been in a substrate solution for naphthol-AS-D-chloroacetate-esterase (CIAE) staining.
Naphthol AS-D chloroacetate has been used as a component of the substrate solution for naphthol-AS-D-chloroacetate-esterase (CIAE) staining to detect:
  • the paraffin-embedded kidney tissues
  • polymorphonuclear (PMN) cells
  • endometrial tissues
  • neutrophils from mice small intestine

Substrates

Substrate for histochemical localization of esterases

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hafez Sadeghi et al.
PloS one, 17(1), e0263409-e0263409 (2022-01-29)
The assessment of polymorphonuclear leukocyte (PMN) proportions (%) of endometrial samples is the hallmark for subclinical endometritis (SCE) diagnosis. Yet, a non-biased, automated diagnostic method for assessing PMN% in endometrial cytology slides has not been validated so far. We aimed
Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury
Maekawa H, et al.
Cell Reports, 29(5), 1261-1273 (2019)
Ivonne Maciel Arciniega-Martínez et al.
Journal of neuroimmunology, 362, 577764-577764 (2021-11-26)
Muscarinic-acetylcholine-receptors (mAChRs) modulate intestinal homeostasis, but their role in inflammation is unclear; thus, this issue was the focus of this study. BALB/c mice were treated for 7 days with muscarine (mAChR/agonist), atropine (mAChR/antagonist) or saline. Small-intestine samples were collected for histology
Antonis Ioannou et al.
American journal of physiology. Gastrointestinal and liver physiology, 304(3), G283-G292 (2012-10-30)
Ischemia-reperfusion (IR) injury causes a vigorous immune response that is amplified by complement activation, leading to local and remote tissue damage. Using MRL/lpr mice, which are known to experience accelerated tissue damage after mesenteric IR injury, we sought to evaluate
Martin Zweifel et al.
Immunology and cell biology, 83(6), 587-595 (2005-11-04)
Mast cells (MC) can undergo significant changes in number and phenotype; these alterations result in the differential expression of growth factors and cytokines. Kit ligand (KL; stem cell factor) is produced by mesenchymal cells, and in the liver by biliary
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