L9919

LY2033298

≥98% (HPLC)

• Synonym(s): 3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methyl-thieno[2,3-b]pyridine-2-carboxamide
• Empirical Formula (Hill Notation): C₁₃H₁₄ClN₃O₂S
• CAS Number: 886047-13-8
• Molecular Weight: 311.79
• MDL number: MFCD12912423
• UNSPSC Code: 12352200
• PubChem Substance ID: 329817677
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: off-white to tan
• solubility: DMSO: >20 mg/mL
• originator: Eli Lilly
• storage temp.: −20°C
• SMILES string: COc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl
• InChI: 1S/C13H14ClN3O2S/c1-5-7-9(15)10(11(18)16-6-3-4-6)20-13(7)17-12(19-2)8(5)14/h6H,3-4,15H2,1-2H3,(H,16,18)
• InChI key: CTEGQKDJTBWFHW-UHFFFAOYSA-N

Description

Biochem/physiol Actions

LY2033298 is a robust allosteric potentiator that is highly selective for the human M4 muscarinic acetylcholine receptor subtype. LY2033298 potentiates ACh-M4 binding, with no effect at M1/3/5 receptors. LY2033298 can also bind to the M ACh receptor, and mediate either positive or negative allosteric effects depending on the ligand used to probe receptor activity.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H334
• Precautionary Statements: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable