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I0899

Sigma-Aldrich

Imipramine hydrochloride

BioXtra, ≥99% (TLC)

Synonym(s):

10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H24N2 · HCl
CAS Number:
113-52-0
Molecular Weight:
316.87
EC Number:
204-030-7
MDL number:
MFCD00012669
UNSPSC Code:
12352116
PubChem Substance ID:
24895912
NACRES:
NA.25

product line

BioXtra

Quality Level

200

Assay

≥99% (TLC)

form

powder

impurities

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

ign. residue

≤0.1%

solubility

H2O: 50 mg/mL, colorless to faintly yellow

anion traces

sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.005%
Cu: ≤0.0005%
Fe: ≤0.005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

SMILES string

Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13

InChI

1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H

InChI key

XZZXIYZZBJDEEP-UHFFFAOYSA-N

Gene Information

human ... SLC6A2(6530) , SLC6A4(6532)

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Application


  • Novel, fast, and reliable electrochemical dsDNA biosensor based on O-terminated pristine nanocrystalline boron-doped diamond electrode for DNA interaction studies.: Research featuring a novel electrochemical dsDNA biosensor that facilitates the study of DNA interactions with imipramine hydrochloride, enhancing our understanding of its genotoxic effects and providing crucial insights for biochemistry applications (Augustín M et al., 2024).

  • Comparison of two pharmacological protocols for inducing ex copula ejaculation in donkeys.: In this comparative study, imipramine hydrochloride is used within a pharmacological protocol, offering significant insights into veterinary applications and animal reproductive studies (Khan FA et al., 2024).

  • Development of Visible Spectrophotometric Methods for the Determination of Tricyclic Antidepressants Based on Formation of Molecular Complexes with p-Benzoquinones.: This publication outlines a novel spectrophotometric method for analyzing tricyclic antidepressants like imipramine hydrochloride, providing an efficient tool for quantitative analysis in pharmaceutical and clinical research (Ciuca MD et al., 2023).

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters with Kis of 7.7 nM and 67 nM, respectively. Has little effect on the dopamine transporter (Ki = 25 μM).

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Steven Chen et al.
Communications biology, 3(1), 747-747 (2020-12-23)
Approximately 10% of the world's population is at risk of schistosomiasis, a disease of poverty caused by the Schistosoma parasite. To facilitate drug discovery for this complex flatworm, we developed an automated high-content screen to quantify the multidimensional responses of
Ana Laura de la Garza et al.
Nutrients, 11(3) (2019-03-15)
Maternal hypercaloric exposure during pregnancy and lactation is a risk factor for developing diseases associated with inflammation such as obesity, diabetes and, neurological diseases in the offspring. Neuroinflammation might modulate neuronal activation and flavonoids are dietary compounds that have been
Tatyana Strekalova et al.
Behavioural brain research, 245, 101-106 (2013-02-26)
Tricyclics and selective serotonin reuptake inhibitors (SSRIs) are probably the most widely employed reference antidepressants in animal studies on depression. Using imipramine and citalopram, we sought to assess which drug would be more appropriate as pharmacological reference in paradigms of
Indrek Saar et al.
Journal of neurochemistry, 127(1), 114-123 (2013-04-23)
Neuropeptide galanin and its three G-protein coupled receptors, galanin receptor type 1-galanin receptor type 3 (GalR1-GalR3), are involved in the regulation of numerous physiological and disease processes, and thus represent tremendous potential in neuroscience research and novel drug lead development.
Ute Krügel et al.
Journal of psychiatric research, 47(5), 611-616 (2013-02-12)
Pro-inflammatory cytokines such as tumour necrosis factor-alpha (TNF-α) have repeatedly been shown to play a pivotal role in the pathophysiology of depression. Therefore, we tested the possible antidepressant-like effect of the anti-TNF-α drug etanercept in an animal model of chronic
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