F3301
Factor Xa chromogenic substrate
chromogenic, ≥90% (HPLC), solid
Synonym(s):
CH3OCO-D-CHA-Gly-Arg-pNA-AcOH
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About This Item
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product name
Factor Xa chromogenic substrate, solid
Assay
≥90% (HPLC)
Quality Level
form
solid
mol wt
apparent mol wt 622.7
solubility
methanol: water (1:9): 25 mg/mL
storage temp.
2-8°C
Application
Factor Xa chromogenic substrate has been used in factor Xa protease assay for placenta organelle protein and Prospirobolus joannsi.
Biochem/physiol Actions
Factor Xa chromogenic substrate contains peptide sequence Bz-Ile-Glu-Gly-Arg-pNA. Factor Xa mediates the release of p-NA chromogen post hydrolysis of substrate which is measurable photometrically.
Physical properties
KM for human factor Xa is ~0.8mM
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Zilei Duan et al.
Cellular and molecular life sciences : CMLS, 79(6), 309-309 (2022-05-22)
Blood clot formation induced by dysfunctional coagulation is a frequent complication of coronavirus disease 2019 (COVID-19) and a high-risk factor for severe illness and death. Neutrophil extracellular traps (NETs) are implicated in COVID-19-induced immunothrombosis. Furthermore, human cathelicidin, a NET component
Probing substrate-induced conformational alterations in adrenoleukodystrophy protein by proteolysis
Guimaraes CP, et al.
Journal of Human Genetics, 50(2), 99-99 (2005)
Pathology consultation on anticoagulation monitoring: factor X-related assays
Wool GD and Lu CM
American Journal of Clinical Pathology, 140(5), 623-634 (2013)
Joannsin, a novel Kunitz-type FXa inhibitor from the venom of Prospirobolus joannsi
Luan N, et al.
Thrombosis and Haemostasis, 117(06), 1031-1039 (2017)
Ning Luan et al.
Thrombosis and haemostasis, 117(6), 1031-1039 (2017-03-10)
The repugnatorial glands of millipedes release various defensive chemical secretions. Although varieties of such defensive secretions have been studied, none of them is protein or peptide. Herein, a novel factor Xa (FXa) inhibitor named joannsin was identified and characterised from repugnatorial glands
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