Skip to Content
Merck
All Photos(4)

Key Documents

View All Documentation

E1379

Sigma-Aldrich

7-Ethoxycoumarin

Synonym(s):

7-Ethoxy-1-benzopyran-2-one

Sign Into View Organizational & Contract Pricing
All Photos(4)

About This Item

Empirical Formula (Hill Notation):
C11H10O3
CAS Number:
31005-02-4
Molecular Weight:
190.20
Beilstein:
146200
EC Number:
250-429-4
MDL number:
MFCD00006877
UNSPSC Code:
12161501
PubChem Substance ID:
24894404
NACRES:
NA.77

Assay

≥99.45% (HPLC)

Quality Level

200

form

powder

mp

88-90 °C (lit.)

solubility

95% ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

fluorescence

λex 323 nm; λem 386 nm

SMILES string

CCOc1ccc2C=CC(=O)Oc2c1

InChI

1S/C11H10O3/c1-2-13-9-5-3-8-4-6-11(12)14-10(8)7-9/h3-7H,2H2,1H3

InChI key

LIFAQMGORKPVDH-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

7-Ethoxycoumarin has been used to study the functional activity of recombinant P450. ) It has also been used as an internal standard for in vitro S-warfarin 7-hydroxylation and high performance liquid chromatography (HPLC) analysis.

Biochem/physiol Actions

7-Ethoxycoumarin is a cytochrome P450 substrate.
Substrate for CYP2B6

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Functional characterization of human CYP2C9 allelic variants in COS-7 cells
Du H, et al.
Frontiers in Pharmacology, 7, 98-98 (2016)
Unravelling the molecular determinants of bee sensitivity to neonicotinoid insecticides
Manjon C, et al.
Current Biology, 28(7), 1137-1143 (2018)
Ying Zhou et al.
Applied microbiology and biotechnology, 87(2), 647-655 (2010-03-13)
Systematic screening of single-gene knockout collection of Escherichia coli BW25113 (the Keio collection) was performed to select mutants that could enhance the deethylation of 7-ethoxycoumarin catalyzed by CYP154A1. After 96-well plate high-throughput screening followed by test tube assays, four mutants
Dong-Hyun Kim et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(11), 2166-2170 (2008-08-02)
Recently, wild-type and mutant forms of bacterial cytochrome P450 BM3 (CYP102A1) have been found to metabolize various drugs through reactions similar to those catalyzed by human cytochromes P450 (P450s). Therefore, it has been suggested that CYP102A1 may be used to
Hiroshi Hamamoto et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 149(3), 334-339 (2008-09-23)
To evaluate the feasibility of using the silkworm as a model animal for screening drug candidates, we examined whether the lethal dose of cytotoxic chemicals in silkworm, Bombyx mori, were consistent with those in mammals, and compared the metabolic pathways
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service