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D8190

Sigma-Aldrich

3′,4′-Dichlorobenzamil hydrochloride

>98% (HPLC)

Synonym(s):

L-594,881

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About This Item

Empirical Formula (Hill Notation):
C13H12N7OCl3 · HCl
CAS Number:
928621-15-2
Molecular Weight:
425.10
MDL number:
MFCD03839362
UNSPSC Code:
12352200
PubChem Substance ID:
24278390
NACRES:
NA.77

Quality Level

100

Assay

>98% (HPLC)

form

solid

color

yellow

solubility

DMSO: soluble 30 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

NC1=NC(N)=C(Cl)N=C1C(NC(NCC2=CC(Cl)=C(Cl)C=C2)=N)=O.Cl

InChI

1S/C13H12Cl3N7O.ClH/c14-6-2-1-5(3-7(6)15)4-20-13(19)23-12(24)8-10(17)22-11(18)9(16)21-8;/h1-3H,4H2,(H4,17,18,22)(H3,19,20,23,24);1H

InChI key

LPHAOBPPRPXQLQ-UHFFFAOYSA-N

Biochem/physiol Actions

Inhibits Na+/Ca2+ exchanger, Na+ transport and sarcoplasmic reticulum Ca2+ release channels.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000227626
115K4611
0000227626
115K46115
115K46114

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C Soto et al.
The Journal of experimental zoology, 289(1), 23-32 (2001-02-13)
The aim of this study was to analyze the relationship of the Na+/Ca2+ exchanger, cytosolic calcium, and chloride to the transepithelial transport of sodium in isolated frog skin. Sodium transport was measured as amiloride-inhibitable short circuit current (SCC). We studied
Manu Hegde et al.
The Journal of pharmacology and experimental therapeutics, 310(1), 67-74 (2004-03-11)
Previously, we demonstrated that malignant glioma cell lines have increased intracellular pH (pHi) as a result of increased activities of the type I sodium/hydrogen exchanger (NHE1). This alkalotic pHi of 7.2 to 7.4 is favorable for augmented glycolysis, DNA synthesis
Shaminder Kaur et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 129(4), 435-443 (2009-04-02)
The present study was designed to investigate the possible neuroprotective effect of digoxin induced pharmacological preconditioning (PP) and its probable mechanism. Bilateral carotid artery occlusion (BCAO) of 17 min followed by reperfusion for 24 h was employed to produce ischemia
Takahiro Horinouchi et al.
European journal of pharmacology, 566(1-3), 28-33 (2007-04-21)
Endothelin ET(A) receptor couples to Gq/11 protein that transduces a variety of receptor signals to modulate diverse cellular responses including Ca2+ mobilization. Stimulation of endothelin ETA receptor with endothelin-1 is generally believed to induce an increase in intracellular Ca2+ concentration
Friedrich Brunner et al.
Cardiovascular research, 60(2), 355-364 (2003-11-14)
The oxidant species peroxynitrite, the reaction product of nitric oxide (NO.) and superoxide, has been implicated in several pathophysiological conditions of the heart. Here, we studied the mechanism of peroxynitrite-induced cardiac depression using specific drugs and simultaneous analyses of myocardial
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