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D1156

Sigma-Aldrich

N,N-Dimethylglycine

≥99%, suitable for ligand binding assays

Synonym(s):

(Dimethylamino)acetic acid

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About This Item

Linear Formula:
(CH3)2NCH2COOH
CAS Number:
1118-68-9
Molecular Weight:
103.12
Beilstein:
1700261
EC Number:
214-267-8
MDL number:
MFCD00004283
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24893366
NACRES:
NA.26

product name

N,N-Dimethylglycine, ≥99%

Quality Level

200

Assay

≥99%

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

mp

178-182 °C (lit.)

application(s)

peptide synthesis

SMILES string

CN(C)CC(O)=O

InChI

1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7)

InChI key

FFDGPVCHZBVARC-UHFFFAOYSA-N

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Biochem/physiol Actions

N,N-Dimethylglycine (DMG) is a natural N-methylated glycine that is used in comparative analysis with other N-methylated glycines such as sarcosine and βine. N,N-Dimethylglycine is used in the development of glycine-based ionic liquids and emulsifiers. N,N-Dimethylglycine is potentially useful as a biomarker of protein degradation in COPD patients. DMG is used as a substrate to identify, differentiate and characterize amino acid methyltransferase(s).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Baljit K Ubhi et al.
The European respiratory journal, 40(2), 345-355 (2011-12-21)
There is a paucity of biomarkers for chronic obstructive pulmonary disease (COPD). Metabolomics were applied to a defined COPD patient cohort from the ECLIPSE study (Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points). Results were correlated with accepted biomarkers
Sheila M Innis et al.
The American journal of clinical nutrition, 93(3), 564-568 (2011-01-14)
Choline is an important constituent of acetylcholine. Choline is needed for acetylcholine in the nonneuronal acetylcholine system that includes epithelial cells of the lung and intestine, endothelial cells, and immune cells. Plasma free choline concentrations are low in children with
Michael Lever et al.
PloS one, 6(7), e21666-e21666 (2011-07-13)
Low plasma betaine has been associated with unfavorable plasma lipid profiles and cardiovascular risk. In some studies raised plasma betaine after supplementation is associated with elevations in plasma lipids. We aimed to measure the relationships between plasma and urine betaine
Isabelle D Kalmar et al.
The British journal of nutrition, 107(11), 1635-1644 (2011-09-21)
N,N-Dimethylglycine (DMG) is a tertiary amino acid that naturally occurs as an intermediate metabolite in choline-to-glycine metabolism. The objective of the present trial was to evaluate tolerance, safety and bioaccumulation of dietary DMG in broilers when supplemented at 1 g
D Vanhauteghem et al.
Amino acids, 43(1), 245-253 (2011-09-14)
The current study first investigates the emulsifying potential of glycine and its N-methylated derivatives N-methylglycine (sarcosine), N,N-dimethylglycine (DMG) and N,N,N-trimethylglycine (betaine) under varying pH conditions. Subsequently, the effect of these test compounds on the membrane integrity of enterotoxigenic Escherichia coli
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