C3167
Corticotropin Releasing Factor sheep
≥95% (HPLC)
Synonym(s):
CRF, CRH
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About This Item
Empirical Formula (Hill Notation):
C205H339N59O63S
CAS Number:
Molecular Weight:
4670.31
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32
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Amino Acid Sequence
Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2
Biochem/physiol Actions
CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.
Releases ACTH and endorphin from the anterior pituitary; central nervous system neurotransmitter.
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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L O E Ebbesson et al.
Journal of neuroendocrinology, 23(8), 733-741 (2011-05-20)
Salmon parr-smolt transformation (smoltification) is a mid-life transitional stage between life in freshwater and seawater that entails a wide range of neural, endocrine and physiological modifications. In salmon, the neuroendocrine corticotropin-releasing factor (CRF) system regulates pituitary adrenocorticotrophic hormone and thyrotrophin
Cun Li et al.
Endocrinology, 154(7), 2365-2373 (2013-04-30)
Intrauterine growth restriction (IUGR) is an important fetal developmental problem resulting from 2 broad causes: maternal undernutrition and/or decreased fetal nutrient delivery to the fetus via placental insufficiency. IUGR is often accompanied by up-regulation of the hypothalamo-pituitary-adrenal axis (HPAA). Sheep
Susan K Wood et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(11), R940-R950 (2013-04-05)
Barrington's nucleus, in the pons, regulates micturition through spinal projections to preganglionic parasympathetic neurons. The stress neuropeptide CRF is prominent in these projections and has an inhibitory influence. Social stress in rats causes urinary retention and abnormal urodynamics resembling those
Yundong Sun et al.
Gastroenterology, 144(7), 1478-1487 (2013-03-09)
Stress alters brain-gut interactions and could exacerbate intestinal disorders, including irritable bowel syndrome. Alterations in the intestinal microbiota have been associated with irritable bowel syndrome. Maintenance of healthy microbiota requires nucleotide-binding oligomerization domain protein-like receptors, pyrin-domain containing (NLRP)-6 inflammasomes. We
Shaobo Yang et al.
Cancer investigation, 31(3), 167-171 (2013-03-13)
The etiology of gastric cancer is unclear; its therapeutic effect is poor; the anatomical factor and lack of specific diagnostic markers are part of the reason. Recent reports indicate corticotropin releasing hormone (CRH) is associated with the pathogenesis of cancer.
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