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A5880

Sigma-Aldrich

D-Amphetamine hemisulfate salt

Synonym(s):

(+)-α-Methylphenethylamine hemisulfate salt, Dextroamphetamine hemisulfate salt

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About This Item

Empirical Formula (Hill Notation):
C9H13N · 0.5 H2SO4
CAS Number:
51-63-8
Molecular Weight:
184.25
EC Number:
200-111-6
MDL number:
MFCD00069209
UNSPSC Code:
12352116
PubChem Substance ID:
24891028
NACRES:
NA.77

form

powder

Quality Level

200

drug control

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada

solubility

H2O: soluble
ethanol: soluble

application(s)

forensics and toxicology

SMILES string

OS(O)(=O)=O.CC(N)Cc1ccccc1.CC(N)Cc2ccccc2

InChI

1S/2C9H13N.H2O4S/c2*1-8(10)7-9-5-3-2-4-6-9;1-5(2,3)4/h2*2-6,8H,7,10H2,1H3;(H2,1,2,3,4)/t2*8-;/m00./s1

InChI key

PYHRZPFZZDCOPH-QXGOIDDHSA-N

Gene Information

human ... SLC18A2(6571)

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Application

D-Amphetamine hemisulfate salt has been used in oxidative fermentative (OF) test, and exploratory test.

Biochem/physiol Actions

D-Amphetamine is an active isomer of amphetamine. It induces release of catecholamines and serotonin by displacing the monoamines from their vesicular storage sites, which blocks catecholamine reuptake.

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Antonio Alcaro et al.
Pharmacology, biochemistry, and behavior, 99(1), 75-80 (2011-04-21)
In mammals, rewarding properties of drugs depend on their capacity to activate a dopamine-mediated appetitive motivational seeking state--a system that allows animals to pursue and find all kinds of objects and events needed for survival. With such states strongly conserved
Stephanie A Carmack et al.
Neuroscience letters, 468(1), 18-22 (2009-10-27)
Much research is focused on developing novel drugs to improve memory. In particular, psychostimulants have been shown to enhance memory and have a long history of safe use in humans. In prior work, we have shown that very low doses
Yan Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(3), 1217-1222 (2010-01-19)
The prairie vole (Microtus ochrogaster) is a socially monogamous rodent species that forms pair bonds after mating, a behavior in which central dopamine (DA) has been implicated. Here, we used male prairie voles to examine the effects of drug exposure
Nina Mansouri-Guilani et al.
Journal of neurochemistry, 148(6), 779-795 (2018-12-18)
Several subtypes of modulatory neurons co-express vesicular glutamate transporters (VGLUTs) in addition to their cognate vesicular transporters. These neurons are believed to establish new forms of neuronal communication. The atypical VGLUT3 is of particular interest since in the striatum this
The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice
Csolle C, et al.
The International Journal of Neuropsychopharmacology, 16(1), 213-233 (2013)
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