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Key Documents

A5356

Sigma-Aldrich

N-Me-Abz-Amyloid β/A4 Protein Precursor770 (708-715)-Lys(Dnp)-D-Arg-D-Arg-D-Arg amide trifluoroacetate salt

≥96% (HPLC), lyophilized powder

Synonym(s):

N-Me-Abz-Amyloid β-Protein (37-44)-Lys(Dnp)-D-Arg-D-Arg-D-Arg amide trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):
C70H116N26O18 · xC2HF3O2
Molecular Weight:
1609.83 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.32

Quality Level

Assay

≥96% (HPLC)

form

lyophilized powder

composition

Peptide content, 92% HPLC

solubility

H2O: >1 mg/mL

shipped in

dry ice

storage temp.

−20°C

Amino Acid Sequence

N-Me-Abz-Gly-Gly-Val-Val-Ile-Ala-Thr-Val-Lys(Dnp)-D-Arg-D-Arg-D-Arg-NH2

Biochem/physiol Actions

A novel intramolecularly quenched fluorescent, presenilin-dependent substrate for assaying γ -secretase activity. It has been used for partial purification and characterization of γ-secretase from post-mortem human brain.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Okay Saydam et al.
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Mehmet Fatih Bolukbasi et al.
Molecular therapy. Nucleic acids, 1, e10-e10 (2013-01-25)
Despite intensive studies, the molecular mechanisms by which the genetic materials are uploaded into microvesicles (MVs) are still unknown. This is the first study describing a zipcode-like 25 nucleotide (nt) sequence in the 3'-untranslated region (3'UTR) of mRNAs, with variants

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