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A4626

Sigma-Aldrich

1-Acetyl-2-phenylhydrazine

≥98%

Synonym(s):

N-Acetyl-N′-phenylhydrazine, acetylphenylhydrazine

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About This Item

Linear Formula:
CH3CONHNHC6H5
CAS Number:
114-83-0
Molecular Weight:
150.18
EC Number:
204-055-3
MDL number:
MFCD00008672
UNSPSC Code:
12352127
PubChem Substance ID:
24890888
NACRES:
NA.25

Quality Level

100

Assay

≥98%

form

(Powder with Chunk(s) or Crystals with Chunk(s))

mp

128-131 °C (lit.)

SMILES string

CC(=O)NNc1ccccc1

InChI

1S/C8H10N2O/c1-7(11)9-10-8-5-3-2-4-6-8/h2-6,10H,1H3,(H,9,11)

InChI key

UICBCXONCUFSOI-UHFFFAOYSA-N

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Application

1-Acetyl-2-phenylhydrazine (AcPhHZ) which reacts with oxyhaemoglobin to form free radicals may be used to induce haemolytic anaemia for studies of the hematopoietic system.

Biochem/physiol Actions

1-Acetyl-2-phenylhydrazine (AcPhHZ) is a vascular tumor initiator used in experimental animal model.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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2,4-Dinitrophenylhydrazine reagent grade, 97%

Sigma-Aldrich

D199303

2,4-Dinitrophenylhydrazine

H Ohno et al.
Fundamental and applied toxicology : official journal of the Society of Toxicology, 20(2), 141-146 (1993-02-01)
DQ-2511, a new anti-ulcer drug, was administered to beagle dogs for 4 weeks to investigate the mechanism whereby this drug induced hemolytic anemia and its reversibility in comparison with beta-acetylphenylhydrazine. Hemolytic anemia accompanied by an increase in the number of
Y Fujii et al.
Journal of electron microscopy, 46(6), 477-484 (1997-01-01)
A new 'tissue-stamp culture' method was developed for stamping proliferating erythroblasts of mouse spleens on collagen-coated coverslips after inducing haemolytic anaemia by administration of 1-acetyl-2-phenylhydrazine, and then adherent splenic cells were cultured for a few days. We could obtain many
R Olinescu et al.
Research communications in chemical pathology and pharmacology, 84(1), 27-34 (1994-04-01)
Following the administration of phenylhydrazine, cadmium chloride and ethanol to rats there was a marked increase in the concentration of liver lipid peroxides and a sharp decline in GSH levels. The oxidative stress generated by the action of these toxic
R S Weinstein et al.
Journal of cell science, 94 ( Pt 3), 593-600 (1989-11-01)
An unusual form of red cells (called sequestrocytes) that circulate in the peripheral blood of patients with sickle cell anemia has been identified. In wetmount light microscopy preparations, sequestrocytes appear as massively vacuolated erythrocytes. We have shown by transmission electron
I Goto et al.
American journal of veterinary research, 54(4), 622-626 (1993-04-01)
To clarify the oxidant defense functions of reduced glutathione (GSH) in erythrocytes, the effect of GSH deficiency on in vitro oxidant defense was studied, using GSH-deficient sheep erythrocytes (low-GSH cells). The formation of Heinz bodies in low-GSH cells was higher
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