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80424

Sigma-Aldrich

Di(N-succinimidyl) glutarate

≥97.0% (CHN)

Synonym(s):

DSG

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About This Item

Empirical Formula (Hill Notation):
C13H14N2O8
CAS Number:
79642-50-5
Molecular Weight:
326.26
Beilstein:
8575145
MDL number:
MFCD00153597
UNSPSC Code:
12161502
PubChem Substance ID:
57652832
NACRES:
NA.25

Quality Level

100

Assay

≥97.0% (CHN)

form

lumps

reaction suitability

reagent type: cross-linking reagent

storage temp.

−20°C

SMILES string

O=C(CCCC(=O)ON1C(=O)CCC1=O)ON2C(=O)CCC2=O

InChI

1S/C13H14N2O8/c16-8-4-5-9(17)14(8)22-12(20)2-1-3-13(21)23-15-10(18)6-7-11(15)19/h1-7H2

InChI key

LNQHREYHFRFJAU-UHFFFAOYSA-N

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Homobifunctional cross-linking reagent; e.g. isolation of insulin receptor

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S M Waugh et al.
Biochemistry, 28(8), 3448-3455 (1989-04-18)
Radiolabeled insulin was affinity cross-linked to purified insulin receptor with six separate bifunctional N-hydroxysuccinimide esters of different lengths. Results were qualitatively identical for each cross-linker in that insulin was predominantly cross-linked through its B chain to the receptor's alpha subunit.
Jing Xu et al.
Cell discovery, 2, 16008-16008 (2016-07-28)
Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in regulating global gene expression in MLLr cells, as well as its interplay with MLL1 fusion
Tariq Afroz et al.
Nature communications, 8(1), 45-45 (2017-07-01)
TDP-43 is a primarily nuclear RNA-binding protein, whose abnormal phosphorylation and cytoplasmic aggregation characterizes affected neurons in patients with amyotrophic lateral sclerosis and frontotemporal dementia. Here, we report that physiological nuclear TDP-43 in mouse and human brain forms homo-oligomers that
Margaret Johnson et al.
Journal of acquired immune deficiency syndromes (1999), 81(4), 463-472 (2019-04-16)
Doravirine is a novel, nonnucleoside reverse transcriptase inhibitor with demonstrated efficacy in treatment-naive adults with HIV-1. In this open-label, active-controlled, noninferiority trial, adults with HIV-1 virologically suppressed for ≥6 months on 2 nucleoside reverse transcriptase inhibitors plus a boosted protease
Anetta Ptasinska et al.
Cell reports, 28(12), 3022-3031 (2019-09-19)
Acute myeloid leukemia (AML) is associated with mutations in transcriptional and epigenetic regulator genes impairing myeloid differentiation. The t(8;21)(q22;q22) translocation generates the RUNX1-ETO fusion protein, which interferes with the hematopoietic master regulator RUNX1. We previously showed that the maintenance of
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