Heparin sodium salt or heparin lithium salt from porcine is typically suitable as an anticoagulant. Any heparin with a CAS number of 9041-08-1 should be suitable. When adding 100 uL of mouse blood, the proper amount of heparin to use would be 1.5 to 3.0 units. It's important to maintain a low ratio of heparin solution to blood, typically around 50 microliters per ml or just 5 microliters per 100 microliters of mouse blood to prevent coagulation.
PHR8927
Heparin sodium
pharmaceutical secondary standard, certified reference material
Synonym(s):
Heparin Sodium for Assays
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grade
certified reference material
pharmaceutical secondary standard
Quality Level
packaging
package of 10MG
application(s)
pharmaceutical
storage temp.
-10 to -25°C
SMILES string
[Na+].[S](=O)(=O)(NC1C(OC(C(C1O[S](=O)(=O)O)OC4OC(C(C(C4O[S](=O)(=O)O)O)O)C(=O)O)CO)OC2C(OC(C(C2O)O[S](=O)(=O)O)OC3C(OC(C(C3O)NC(=O)C)O)CO[S](=O)(=O)O)C(=O)O)O
InChI key
JRTRSJGZMRQDHI-UHFFFAOYSA-N
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General description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Heparin, also known as unfractionated heparin (UFH), is an anticoagulant drug widely used in the treatment of heart attacks. Heparin exerts its anticoagulant effect by potentiating the activity of plasma coagulation inhibitors.
Of all the commonly known glycosaminoglycans, only heparin contains a specific pentasaccharide sequence that can bind to the plasma coagulation inhibitor, antithrombin (AT). Heparin is not a thrombolytic, it prevents progression of existing clots by inhibiting further clotting.
Heparin, also known as unfractionated heparin (UFH), is an anticoagulant drug widely used in the treatment of heart attacks. Heparin exerts its anticoagulant effect by potentiating the activity of plasma coagulation inhibitors.
Of all the commonly known glycosaminoglycans, only heparin contains a specific pentasaccharide sequence that can bind to the plasma coagulation inhibitor, antithrombin (AT). Heparin is not a thrombolytic, it prevents progression of existing clots by inhibiting further clotting.
Application
Heparin Sodium for Assays pharmaceutical secondary standard is intended for use as a working standard for quantitative applications.
Features and Benefits
- The potency of Heparin is directly dependent on the Antifactor IIa and Xa potency, it is a critical parameter in the quality control of Heparin production.
- Certified potency value of the pharma secondary product can be used to compare and determine the potency of the Heparin sample.
- The potency of this product is certified by comparison against USP Heparin for Assays (RS).
- The assay to determine the anti-factor potency of Heparin PHR was developed based on the USP General Chapter method <208>.
- Both the factor IIa and Xa potency were determined by a chromogenic assay.
Analysis Note
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Other Notes
This secondary biopharma certified reference material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
This product′s purpose is for testing. THIS PRODUCT IS NOT INTENDED FOR HUMAN OR THERAPEUTIC USE.
This product′s purpose is for testing. THIS PRODUCT IS NOT INTENDED FOR HUMAN OR THERAPEUTIC USE.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Could you please specify the type of heparin that should be used as an anticoagulant to prevent blood from coagulating? Additionally, if needing to add to 100 uL of mouse blood, how many units of heparin should be used?
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