Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
PHR8927
Heparin sodium
pharmaceutical secondary standard, certified reference material
Synonym(s):
Heparin Sodium for Assays
About This Item
Recommended Products
grade
certified reference material
pharmaceutical secondary standard
Quality Level
packaging
package of 10MG
application(s)
pharmaceutical
storage temp.
-10 to -25°C
SMILES string
[Na+].[S](=O)(=O)(NC1C(OC(C(C1O[S](=O)(=O)O)OC4OC(C(C(C4O[S](=O)(=O)O)O)O)C(=O)O)CO)OC2C(OC(C(C2O)O[S](=O)(=O)O)OC3C(OC(C(C3O)NC(=O)C)O)CO[S](=O)(=O)O)C(=O)O)O
InChI key
JRTRSJGZMRQDHI-UHFFFAOYSA-N
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General description
Heparin, also known as unfractionated heparin (UFH), is an anticoagulant drug widely used in the treatment of heart attacks. Heparin exerts its anticoagulant effect by potentiating the activity of plasma coagulation inhibitors.
Of all the commonly known glycosaminoglycans, only heparin contains a specific pentasaccharide sequence that can bind to the plasma coagulation inhibitor, antithrombin (AT). Heparin is not a thrombolytic, it prevents progression of existing clots by inhibiting further clotting.
Application
Features and Benefits
- The potency of Heparin is directly dependent on the Antifactor IIa and Xa potency, it is a critical parameter in the quality control of Heparin production.
- Certified potency value of the pharma secondary product can be used to compare and determine the potency of the Heparin sample.
- The potency of this product is certified by comparison against USP Heparin for Assays (RS).
- The assay to determine the anti-factor potency of Heparin PHR was developed based on the USP General Chapter method <208>.
- Both the factor IIa and Xa potency were determined by a chromogenic assay.
Analysis Note
Other Notes
This product′s purpose is for testing. THIS PRODUCT IS NOT INTENDED FOR HUMAN OR THERAPEUTIC USE.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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Could you please specify the type of heparin that should be used as an anticoagulant to prevent blood from coagulating? Additionally, if needing to add to 100 uL of mouse blood, how many units of heparin should be used?
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Heparin sodium salt or heparin lithium salt from porcine is typically suitable as an anticoagulant. Any heparin with a CAS number of 9041-08-1 should be suitable. When adding 100 uL of mouse blood, the proper amount of heparin to use would be 1.5 to 3.0 units. It's important to maintain a low ratio of heparin solution to blood, typically around 50 microliters per ml or just 5 microliters per 100 microliters of mouse blood to prevent coagulation.
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