Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
PHR1855
Telmisartan
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
Telmisartan, 4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl][1,1′-biphenyl]-2-carboxylic acid, BIBR 277
About This Item
Recommended Products
grade
certified reference material
pharmaceutical secondary standard
Quality Level
Agency
traceable to Ph. Eur. Y0000648
traceable to USP 1643419
API family
telmisartan
CofA
current certificate can be downloaded
packaging
pkg of 500 mg
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
CCCc1nc2c(C)cc(cc2n1Cc3ccc(cc3)-c4ccccc4C(O)=O)-c5nc6ccccc6n5C
InChI
1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
InChI key
RMMXLENWKUUMAY-UHFFFAOYSA-N
Gene Information
human ... AGTR1(185)
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General description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Telmisartan belongs to the class of angiotensin II receptor antagonists (ARAs) used in the treatment of hypertension.
Application
- Reversed-phase high-performance liquid chromatography (RP-HPLC) method-based multi-analysis of rosuvastatin, telmisartan, ezetimibe, and atorvastatin in pharmaceutical dosage formulations[1]
- RP-HPLC analysis of telmisartan in the presence of its three impurities in its tablet formulation following an analytical quality-by-design (AQbD) approach[2]
- Multi-determination of hydrochlorothiazide, amlodipine, and telmisartan by HPLC combined with spectrometric techniques without derivatization
- Simultaneous estimation of telmisartan and hydrochlorothiazide by micellar high-pressure liquid chromatography and spectrophotometry-based methods in their combined tablet formulations[3]
- RP-HPLC method-based determination of four cardiovascular drugs—atorvastatin, simvastatin, telmisartan, and irbesartan in bulk drugs and tablet dosage forms, following ICH guidelines
Biochem/physiol Actions
Analysis Note
Footnote
related product
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Certificates of Analysis (COA)
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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