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434760

Sigma-Aldrich

Benzamidine hydrochloride

99%

Synonym(s):

Amidinobenzene hydrochloride, Benzamidinium chloride

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About This Item

Linear Formula:
C6H5C(=NH)NH2 · HCl
CAS Number:
1670-14-0
Molecular Weight:
156.61
Beilstein:
3594959
EC Number:
216-795-4
MDL number:
MFCD00013025
UNSPSC Code:
12352106
PubChem Substance ID:
24867207
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

200

Assay

99%

form

beads

mp

169-173 °C (lit.)

solubility

water: soluble

SMILES string

Cl.NC(=N)c1ccccc1

InChI

1S/C7H8N2.ClH/c8-7(9)6-4-2-1-3-5-6;/h1-5H,(H3,8,9);1H

InChI key

LZCZIHQBSCVGRD-UHFFFAOYSA-N

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Application

<ul>
<li><strong>Purification and characterization of a serine protease from organic dust and elucidation of its inductive effects on lung i</strong></li>
<li><strong>Preclinical testing of dabigatran in trypsin-dependent pancreatitis:</strong> This research uses Benzamidine hydrochloride to inhibit serine proteases in models of pancreatitis, highlighting its potential in preclinical studies to evaluate new therapeutic approaches for inflammatory and digestive disorders (Pesei et al., 2022).</li>
</ul>

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000358947
0000358947
0000256897
WXBF0199V
MKCS9599

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Seweryn Mroczek et al.
Nature communications, 8(1), 619-619 (2017-09-22)
FAM46C is one of the most frequently mutated genes in multiple myeloma. Here, using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active non-canonical poly(A) polymerase which enhances mRNA stability and gene expression.
Zaofeng Yang et al.
iScience, 23(6), 101158-101158 (2020-05-29)
The effectiveness of cancer radiotherapy is frequently hindered by the hypoxia of the tumor microenvironment. Direct delivery of oxygen to hypoxic tumor tissues is an attractive strategy to overcome this hypoxia-associated radioresistance. Herein, we report the generation of submicron-sized particles
Bradley S Heater et al.
Biotechnology for biofuels, 12, 165-165 (2019-07-13)
We have recently developed a one-step, genetically encoded immobilization approach based on fusion of a target enzyme to the self-crystallizing protein Cry3Aa, followed by direct production and isolation of the fusion crystals from Bacillus thuringiensis. Using this approach, Bacillus subtilis
Joris Van Lindt et al.
Communications biology, 4(1), 77-77 (2021-01-21)
Understanding the kinetics, thermodynamics, and molecular mechanisms of liquid-liquid phase separation (LLPS) is of paramount importance in cell biology, requiring reproducible methods for studying often severely aggregation-prone proteins. Frequently applied approaches for inducing LLPS, such as dilution of the protein
Anita de Ruiter et al.
Journal of computational chemistry, 34(12), 1024-1034 (2013-01-22)
The performances of Bennett's acceptance ratio method and thermodynamic integration (TI) for the calculation of free energy differences in protein simulations are compared. For the latter, the standard trapezoidal rule, Simpson's rule, and Clenshaw-Curtis integration are used as numerical integration
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Questions

1–6 of 6 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. What is Product 434760, Benzamidine hydrochloride, soluble in?

    1 answer

    1. We would expect benzamidine hydrochloride to be soluble in water to at least 50 mg/mL. However, gentle heating may be required to solubilize it at this concentration.

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  4. What can Product 434760, Benzamidine hydrochloride, be used for?

    1 answer

    1. Benzamidine hydrochloride has been shown to act as a reversible inhibitor of trypsin, trypsin-like enzymes and serine proteases.

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  5. Does Product 434760, Benzamidine hydrochloride, contain waters of hydration?

    1 answer

    1. Sigma-Aldrich does not measure the water content directly of this product. However, based on the way the material is produced and handled, we would not expect any waters of hydration to be present. The corresponding hydrate product is found under Product No. B6506.

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  6. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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