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15269

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N,O-Bis(trimethylsilyl)acetamide

for GC derivatization, LiChropur™, ≥98.5% (GC)

Synonym(s):

BSA

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About This Item

Linear Formula:
CH3C[=NSi(CH3)3]OSi(CH3)3
CAS Number:
10416-59-8
Molecular Weight:
203.43
Beilstein:
1306669
EC Number:
233-892-7
MDL number:
MFCD00008270
UNSPSC Code:
41116105
PubChem Substance ID:
329750807
NACRES:
NA.22

grade

for GC derivatization

Quality Level

100

Assay

≥98.5% (GC)

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.417 (lit.)
n20/D 1.417

bp

71-73 °C/35 mmHg (lit.)

density

0.832 g/mL at 20 °C (lit.)

SMILES string

C\C(O[Si](C)(C)C)=N/[Si](C)(C)C

InChI

1S/C8H21NOSi2/c1-8(9-11(2,3)4)10-12(5,6)7/h1-7H3/b9-8+

InChI key

SIOVKLKJSOKLIF-CMDGGOBGSA-N

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General description

N,O-Bis(trimethylsilyl)acetamide is an excellent silylation reagent. For some sterically hindered primary or secondary nitro compounds, N,O-bis(trimethylsilyl)acetamide and BSTFA achieve better results than normal silylation conditions.

Application

Learn more in the Product Information
Suitable for the derivatization of 2-amino-2-dexoxyhexoses, ecdysones, hexosamines in glycosaminoglycans, 18-hydroxycorticosteroids, 15-Oxo-prostaglandin F2α, prostaglandins A,B and E and F, F2α, prostaglandins and metabolites, prostaglandins Emetabolites, sugar phosphates, steroids and testosterone.

Other Notes

Powerful silylating agent
Reagent for o-trimethylsilyl-aldono-1,4-lactones, trimethylsilyl and trimethylsilyl ether.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

Signal Word

Danger

Hazard Statements

H226,H302,H314

Hazard Classifications

Acute Tox. 4 Oral - Flam. Liq. 3 - Skin Corr. 1B

Supplementary Hazards

EUH014

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

111.2 °F - closed cup

Flash Point(C)

44 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL5983
BCCL8147
BCCK0041
BCCJ3420
BCCJ4386

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J. Heberle et al.
Silylating Agents, 2nd ed. (1995)
K. Blau et al.
Handbook of Derivatives for Chromatography (1993)
Analysis of the prostaglandins E by glass capillary gas chromatography with electron capture detection.
M Korteweg et al.
Prostaglandins, 13(6), 1221-1223 (1977-06-01)
Houben-Weyl Methods of Molecular Transformations. Heteroatom Analogues of Aldehydes and Ketones.
Aggarwal VK
Science of Synthesis Knowledge Updates, 27, 593-594 (2014)
Anna Hjelm et al.
Applied and environmental microbiology, 81(2), 726-735 (2014-11-16)
Bacterial ghosts are empty cell envelopes of Gram-negative bacteria that can be used as vehicles for antigen delivery. Ghosts are generated by releasing the bacterial cytoplasmic contents through a channel in the cell envelope that is created by the controlled
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