MAB4150
Anti-MRP2 Antibody, CT, clone M2 III-6
culture supernatant, clone M2 III-6, Chemicon®
Synonym(s):
cMOAT
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
mouse
Quality Level
antibody form
culture supernatant
antibody product type
primary antibodies
clone
M2 III-6, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
isotype
IgG2a
NCBI accession no.
UniProt accession no.
shipped in
wet ice
Gene Information
human ... ABCC2(1244)
Specificity
This antibody reacts with an internal epitope of MRP2, a 190-200 kDa transmembrane protein previously known as the canalicular multi-organic anion transporter (cMOAT). MRP2 is a member of the MRP family of multidrug resistance related proteins, and MRP2 over expression has been observed in a subset of cisplatin resistant cell lines. This antibody does not cross-react with the human MDR1, MRP1, MRP3 or MRP5 gene products.
Immunogen
Bacterial fusion protein of MRP2 containing the 202-aa C-terminal end
Epitope: C-terminus
Application
Detect MRP2 using this Anti-MRP2 Antibody, C-terminus, clone M2 III-6 validated for use in WB, IC, IH, IH(P).
Research Category
Metabolism
Metabolism
Research Sub Category
Toxicology & Drug Resistance
Toxicology & Drug Resistance
Western blotting: 1:20 - 1:50 with anti-mouse HRP
Immunocytochemistry: 1:20 - 1:50 on acetone fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections; 1:20 on formaldehyde-fixed paraffin-embedded tissues (pretreat with 0.01M citrate, pH 6.0, in dH2O at 100ºC for 5 minutes, repeated 3 times)
Optimal working dilutions must be determined by end user.
Immunocytochemistry: 1:20 - 1:50 on acetone fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections; 1:20 on formaldehyde-fixed paraffin-embedded tissues (pretreat with 0.01M citrate, pH 6.0, in dH2O at 100ºC for 5 minutes, repeated 3 times)
Optimal working dilutions must be determined by end user.
Physical form
Liquid containing 0.7% BSA and 0.1% sodium azide.
Storage and Stability
Maintain refrigerated at 2-8°C for up to 6 months. For long-term storage store at -20°C.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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C C Paulusma et al.
Science (New York, N.Y.), 271(5252), 1126-1128 (1996-02-23)
The human Dubin-Johnson syndrome and its animal model, the TR(-) rat, are characterized by a chronic conjugated hyperbilirubinemia. TR(-) rats are defective in the canalicular multispecific organic anion transporter (cMOAT), which mediates hepatobiliary excretion of numerous organic anions. The complementary
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UNC45A is a myosin (co-)chaperone, and mutations in the UNC45A gene were recently identified in osteo-oto-hepato-enteric (O2HE) syndrome patients presenting with congenital diarrhea and intrahepatic cholestasis. Congenital diarrhea and intrahepatic cholestasis are also the prime symptoms in patients with microvillus
Cifford W Mason et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(6), 1000-1007 (2011-03-25)
Fetal drug exposure is determined by the type and concentration of placental transporters, and their regulation is central to the development of new treatments and delivery strategies for pregnant women and their fetuses. We tested the expression of several clinically
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