100069
17-DMAG
A potent antitumor analog of 17-AAG that binds to the ATPase site of human Hsp90α with high affinity and displays excellent bioavailability and aqueous solubility.
Synonym(s):
17-DMAG, NSC 707545, 17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl, 17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl, 17DMAG
About This Item
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Quality Level
Assay
≥95% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
purple
solubility
water: 10 mg/mL
DMSO: 5 mg/mL
shipped in
wet ice
storage temp.
−20°C
InChI
1S/C32H48N4O8.ClH/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8;/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40);1H/b11-9-,19-10+,21-16+;/t18-,20+,25+,26+,28-,30+;/m1./s1
1 of 4
This Item | BP695 | L0702000 | Y0001709 |
---|---|---|---|
≥98% (HPLC) | - | - | - |
2-8°C | 2-8°C | 2-8°C | 2-8°C |
H2O: ≥10 mg/mL, DMSO: ~6.5 mg/mL (with heating and sonicating) | - | - | - |
white | - | - | - |
human ... ACE(1636) | human ... ACE(1636) | human ... ACE(1636) | human ... ACE(1636) |
General description
Biochem/physiol Actions
17-DMAG
Packaging
Warning
Reconstitution
Other Notes
Jez, J.M., et al. 2003. Chem. Biol.10, 361.
Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol.49, 7.
Legal Information
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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