Skip to Content
Merck
All Photos(2)

Key Documents

View All Documentation

850371P

Avanti

22:0 PC

1,2-dibehenoyl-sn-glycero-3-phosphocholine, powder

Synonym(s):

1,2-didocosanoyl-sn-glycero-3-phosphocholine; PC(22:0/22:0)

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Empirical Formula (Hill Notation):
C52H104NO8P
CAS Number:
37070-48-7
Molecular Weight:
902.36
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (850371P-1g)
pkg of 1 × 25 mg (850371P-25mg)
pkg of 1 × 500 mg (850371P-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850371P

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCCCCCC)=O)=O

InChI

1S/C52H104NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-40-42-44-51(54)58-48-50(49-60-62(56,57)59-47-46-53(3,4)5)61-52(55)45-43-41-39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h50H,6-49H2,1-5H3

InChI key

HRTBOPUWPUXROO-UHFFFAOYSA-N

General description

Phosphatidylcholines (PCs) are amphipathic molecules, that are mainly located on the outer leaflets of the biological membrane bilayer. Approximately 40–50% of the total cellular phospholipids consists of phosphatidylcholine.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

22:0 PC may be used:
  • to study its effects on non-amyloidogenic processing of amyloid precursor protein (APP)/α-secretase activity
  • to prepare a lipid monolayer to study whether ligand is specifically targeted to domains containing Cu(II)-iminodiacetate lipid (Cu-PSIDA)
  • as a lipid standard for the quantification of lipid species from lipid droplets by hydrophilic interaction liquid chromatography-high performance liquid chromatography (HILIC-HPLC)

Biochem/physiol Actions

Phosphatidylcholines (PCs) can serve as lung surfactant.

Packaging

20 mL Clear Glass Screw Cap Vial (850371P-1g)
20 mL Clear Glass Screw Cap Vial (850371P-500mg)
5 mL Amber Glass Screw Cap Vial (850371P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Elinor Thompson et al.
Healthcare technology letters, 6(5), 138-142 (2019-12-14)
Oxygen loaded microbubbles are being investigated as a means of reducing tumour hypoxia in order to improve response to cancer therapy. To optimise this approach, it is desirable to be able to measure changes in tissue oxygenation in real-time during
K Maloney et al.
Chemistry & biology, 3(3), 185-192 (1996-03-01)
Chemical information is sometimes transmitted across cell membranes by ligand-induced assembly of receptors. We have previously designed a series of lipids with metal-chelating headgroups that can serve as general receptors for proteins containing accessible histidines. Such lipids can also be
Estelle Beguin et al.
Journal of controlled release : official journal of the Controlled Release Society, 317, 23-33 (2019-11-17)
Recent pre-clinical studies have demonstrated the potential of combining chemotherapy and sonodynamic therapy for the treatment of pancreatic cancer. Oxygen-loaded magnetic microbubbles have been explored as a targeted delivery vehicle for this application. Despite preliminary positive results, a previous study
Pinunta Nittayacharn et al.
Frontiers in pharmacology, 11, 644-644 (2020-06-02)
Drug delivery to solid tumors using echogenic nanobubbles (NBs) and ultrasound (US) has recently gained significant interest. The approach combines attributes of nanomedicine and the enhanced permeation and retention (EPR) effect with the documented benefits of ultrasound to improve tumor
Bingbing Cheng et al.
Scientific reports, 9(1), 20020-20020 (2019-12-29)
Real-time acoustic feedback control based on harmonic emissions of stimulated microbubbles may be important for facilitating the clinical adoption of focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening, both to ensure safe acoustic exposures, and to achieve repeatable and consistent opening.
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service