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D7631

Sigma-Aldrich

5,5-Dimethyl-2,4-oxazolidinedione

Synonym(s):

DMO, Dimethadione, NSC 30152

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About This Item

Empirical Formula (Hill Notation):
C5H7NO3
CAS Number:
695-53-4
Molecular Weight:
129.11
EC Number:
211-781-4
MDL number:
MFCD00005379
UNSPSC Code:
12352100
PubChem Substance ID:
57654127
NACRES:
NA.22

form

powder

Quality Level

200

mp

77-80 °C (lit.)

storage temp.

2-8°C

SMILES string

CC1(C)OC(=O)NC1=O

InChI

1S/C5H7NO3/c1-5(2)3(7)6-4(8)9-5/h1-2H3,(H,6,7,8)

InChI key

JYJFNDQBESEHJQ-UHFFFAOYSA-N

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Application

Reactant involved in:
  • Synthesis of nickel benzoannulated or naphthoannulated β-oxatetraazachlorin complex
  • Being used as a cathepsin K inhibitor

Molecule involved in pharmacological studies including:
  • Identification of bioequivalent generic substitute for antiepileptic drugs
  • Screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
  • Dissolving protein plugs in patients with choledochal cyst / pancreaticobiliary maljunctions

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302 + H312 + H332,H351

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000363050
0000363054
0000363056
0000363057
0000363057

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O M Ocon et al.
Journal of dairy science, 86(4), 1194-1200 (2003-05-14)
Feeding cattle diets high in degradable crude protein (CP) or in excess of requirements can reduce fertility and lower uterine pH. Objectives were to determine direct effects of urea and acidic pH during oocyte maturation and embryonic development. For experiment
Catharina Busch et al.
Acta ophthalmologica, 98(7), e801-e806 (2020-03-03)
To investigate clinical baseline characteristics and optical coherence tomography biomarkers predicting visual loss during observation in eyes with diabetic macular oedema (DMO) and good baseline visual acuity (VA). A sub-analysis of a 12-month, retrospective study, including patients with baseline VA
Deirdre L Zander-Fox et al.
Reproductive biomedicine online, 21(2), 219-229 (2010-07-10)
The preimplantation embryo is highly susceptible to in-vitro stress, and although this does not necessarily perturb blastocyst development, it can significantly affect embryo physiology and the ability to form a viable pregnancy. This study determined that the preimplantation mouse embryo
Matias Iglicki et al.
The British journal of ophthalmology, 104(5), 666-671 (2019-08-09)
We aimed to investigate a novel optical coherence tomography (OCT) finding of outer retinal hyperreflective deposits (ORYDs) in patients with naïve diabetic macular oedema (DMO) seen after small gauge pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling. Furthermore
Sanjeeb Bhandari et al.
Clinical & experimental ophthalmology, 48(4), 462-469 (2019-12-31)
There are limited data on real-world outcomes of cataract surgery in eyes receiving intravitreal treatments for diabetic macular oedema (DMO). Cataract surgery may exacerbate oedema in some eyes with DMO resulting in inferior outcomes. Matched, case-controlled retrospective study of observational
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