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Sigma-Aldrich

NanoFabTx™ - Azide Lipid Mix

for synthesis of azide-functionalized liposomes

Synonym(s):

Azide-PEG-DSPE, Cholesterol, HSPC, PEG-PE

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About This Item

UNSPSC Code:
12352211
NACRES:
NA.25

Quality Level

100

storage temp.

−20°C

Application

The NanoFabTx™ Azide Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of azide-functionalized liposomes, which can be used for targeting and immunotherapy applications, and small molecule encapsulation.

This product is a curated lyophilized lipid mixture of rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis azide-functionalized liposomes by extrusion and microfluidics are included. The synthesized azide-functionalized liposomes enables the conjugation of DBCO or alkyne-modified antibodies, proteins, aptamers, or other molecules to the liposomes surface which can be used for multi-targeting or multi-type cargo delivery to difference cell types including immune cells.

Features and Benefits

  • A ready-to-use nanoformulation lipid blend to synthesize azide-functionalized liposomes
  • Step-by-step protocols developed and tested by our formulation scientists
  • Flexible synthesis tool to create uniform and reproducible liposomes
  • Optimized to make liposomes around 100 nm with low polydispersity
  • Optimized lipid blend for DBCO-modified protein or antibody conjugation
  • Optimized lipid blend for azide-functionalized liposomes for small molecule encapsulation
For microfluidic liposome synthesis of azide-functionalized liposomes, the NanoFabTx™- Azide Lipid Mix can be used with the the NanoFabTx™ Microfluidic - nano device kit (Cat.No. 911593). The NanoFabTx™ Microfluidic - nano device kit includes the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Li Shen et al.
ACS omega, 5(23), 14111-14115 (2020-06-23)
Two Ac4ManNAz (AAM) derivatives with octadecanoic ester (C18 ester) and octadecyl ether (C18 ether) attached to the anomeric hydroxyl groups were synthesized and used in preparation of liposomes. Both liposomes show strong cell-labeling efficiencies on MDA-MB-231 cancer cells. The cell
Lin Wang et al.
Journal of bioscience and bioengineering, 124(4), 445-451 (2017-07-12)
Thrombomodulin (TM) is an endothelial cell membrane protein that acts as a major cofactor in the protein C anticoagulant pathway. The EGF-like domains 4-6 of TM (TM456) are essential for PC activation. In this study, we proposed a liposomal recombinant
Daxing Liu et al.
Nature communications, 9(1), 2612-2612 (2018-07-06)
The C-X-C chemokine receptor type 4 (CXCR4, CD184) pathway is a key regulator of cancer metastasis. Existing therapeutics that block CXCR4 signaling are dependent on single molecule-receptor interactions or silencing CXCR4 expression. CXCR4 localizes in lipid rafts and forms dimers
Yunxin Xiao et al.
Colloids and surfaces. B, Biointerfaces, 182, 110362-110362 (2019-07-28)
Liposomal formulations have important therapeutic applications in anti-cancer treatments but current formulations suffer from serious side effects, high dosage requirements and prolonged treatment. In this study, PEGylated azide-functionalized liposomes containing drug nanocrystals were investigated with the aim of increasing the
Elizabeth D Hood et al.
Bioconjugate chemistry, 29(11), 3626-3637 (2018-09-22)
Liposomes are a proven, versatile, and clinically viable technology platform for vascular delivery of drugs and imaging probes. Although targeted liposomes have the potential to advance these applications, complex formulations and the need for optimal affinity ligands and conjugation strategies

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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