923788
HumaTein™ MSC bioink
derived from primary human mesenchymal stem cell culture, suitable for 3D bioprinting applications
Synonym(s):
3D bioprinting, 3DBP, ECM
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About This Item
UNSPSC Code:
12352201
NACRES:
NA.25
Recommended Products
Quality Level
composition
Bioink lyophilized powder
impurities
<0.12 EU/mg Endotoxin
storage temp.
−20°C
Application
HumaTein™ MSC bioink is based on whole ECM derived from primary human BM-MSC culture, and it′s suitable for 3D bioprinting applications. Whole ECM consists of more than 300 components includes collagen family, laminin, fibronectin, glycosaminoglycans and reserves more than 500 cytokines in balanced composition that regulate cell phenotype and function for tissue homeostasis in development. HumaTein MSC provides a rich ECM environment to promote cellular proliferation. HumaTein MSC contains human extracellular matrix components including collagens, laminin, fibronectin, tenascin, elastin, and a number of proteoglycans and glycosaminoglycans.
The cell culture derived human whole ECM effectively recapitulates tissue micro-environment during development and in organotypic cell culture. It promotes cell growth and migration and has been shown to support the proliferation of many cell types, including human embryonic stem cells, neural stem cells, endothelial cells, MSC, pericytes, fibroblasts, hepatocytes, skeletal muscle cell, smooth muscle cell, and keratinocytes. This cell culture derived human whole ECM is not denatured nor chloroform sterilized. It provides for a more tissue-like environment, due to the 3D folding structure preserved ECM proteins, which provides scaffolding structure for cell attachment, growth and migration.
The cell culture derived human whole ECM effectively recapitulates tissue micro-environment during development and in organotypic cell culture. It promotes cell growth and migration and has been shown to support the proliferation of many cell types, including human embryonic stem cells, neural stem cells, endothelial cells, MSC, pericytes, fibroblasts, hepatocytes, skeletal muscle cell, smooth muscle cell, and keratinocytes. This cell culture derived human whole ECM is not denatured nor chloroform sterilized. It provides for a more tissue-like environment, due to the 3D folding structure preserved ECM proteins, which provides scaffolding structure for cell attachment, growth and migration.
Legal Information
HumaTein is a trademark of Rokit Healthcare, Inc.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
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Yuanheng Yang et al.
Acta biomaterialia, 69, 71-82 (2018-01-11)
Mesenchymal stem cell derived extracellular matrix (MSC-ECM) is a natural biomaterial with robust bioactivity and good biocompatibility, and has been studied as a scaffold for tissue engineering. In this investigation, we tested the applicability of using decellularized human bone marrow
Kevin Dzobo et al.
International journal of molecular sciences, 20(18), 4628-4628 (2019-09-22)
The promise of regenerative medicine and tissue engineering is founded on the ability to regenerate diseased or damaged tissues and organs into functional tissues and organs or the creation of new tissues and organs altogether. In theory, damaged and diseased
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