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911518

Sigma-Aldrich

Polyester bis-MPA dendron 8 NHBoc, 1 NHS (core)

generation 3

Synonym(s):

Bis-MPA dendron, NHS-NHBoc dendron

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About This Item

Empirical Formula (Hill Notation):
C103H165N9O48
Molecular Weight:
2297.44
UNSPSC Code:
12162002
NACRES:
NA.23

Pricing and availability is not currently available.

description

8 NHBoc, 1 NHS (core)

form

solid (Viscous)

mol wt

generation 3

no. Surface Groups

8

color

colorless to white

functional group

(NHS(core))

storage temp.

−20°C

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RAB0056RAB0471RAB0470
Gene Information

rat ... Ccl2(24770)

Gene Information

mouse ... Ccl2(20296)

Gene Information

rat ... Timp1(116510)

Gene Information

rat ... Timp1(116510)

input

sample type cell lysate
sample type tissue lysate

input

sample type cell lysate
sample type tissue lysate

input

sample type tissue lysate
sample type cell lysate

input

sample type plasma
sample type serum
sample type cell culture supernatant(s)

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 15 pg/mL
standard curve range: 24.67-18000 pg/mL

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 3 pg/mL
standard curve range: 2.74-2000 pg/mL

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 4 pg/mL
standard curve range: 4.1-3000 pg/mL

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 4 pg/mL
standard curve range: 4.1-3000 pg/mL

technique(s)

ELISA: suitable, capture ELISA: suitable

technique(s)

ELISA: suitable, capture ELISA: suitable

technique(s)

ELISA: suitable, capture ELISA: suitable

technique(s)

ELISA: suitable, capture ELISA: suitable

packaging

kit of 96 wells (12 strips x 8 wells)

packaging

kit of 96 wells (12 strips x 8 wells)

packaging

kit of 96 wells (12 strips x 8 wells)

packaging

kit of 96 wells (12 strips x 8 wells)

General description

  • Polymer architecture: Dendron
  • End Group Functionality: NHBoc
  • Bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid

Application

Bis-MPA dendritic molecules are based on 2,2-bismethylolpropionicacid (bis-MPA) building blocks. The hydrolysable linkers presented in this type of polymers allows their degradation into byproducts that can be reabsorbed by the body or into excretable non-toxic small molecules. Therefore, this group of dendritic polymers are biocompatible and biodegradable, making them suitable for biomedical applications. The NHBoc-functionalized corona and NHS-functionalized core of this product can be readily used in bioconjugation reactions.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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    Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications
    Garcia-Gallego S, et al
    Progress in Polymer Science, 48, 85-110 (2015)
    Anna Carlmark et al.
    Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
    Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

    Articles

    Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

    Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

    Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

    Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

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