900893

L-Homopropargylglycine hydrochloride

• Synonym(s): HPG
• Empirical Formula (Hill Notation): C₆H₉NO₂ · HCl
• CAS Number: 98891-36-2
• Molecular Weight: 163.60
• UNSPSC Code: 12352209
• NACRES: NA.22

Properties

• form: powder or crystals
• availability: available only in USA
• mp: 162 °C
• storage temp.: −20°C
• SMILES string: O=C(O[H])[C@@](C([H])([H])C([H])([H])C#C[H])([H])N([H])[H].Cl[H]
• InChI: 1S/C6H9NO2/c1-2-3-4-5(7)6(8)9/h1,5H,3-4,7H2,(H,8,9)
• InChI key: SCGJGNWMYSYORS-UHFFFAOYSA-N

Description

Application

L-Homopropargylglycine (HPG) is an amino acid analog of methionine that contains a very small modification, specifically an alkyne moiety. This compound can be fed to cultured cells and incorporated into proteins during active protein synthesis. Detection utilizes the chemoselective ligation or “click” reaction between an azide and an alkyne or cyclooctyne. For example the alkyne-modified protein can be detected with either fluorescent azide or biotin azide. Detection sensitivity with these reagents in 1-D gels and Western blots is in the low femtomole range and compatible with downstream LC-MS/MS and MALDI-MS analysis.

Safety Information

• Pictograms: GHS02
• Signal Word: Danger
• Hazard Statements: H242
• Precautionary Statements: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Hazard Classifications: Self-react. C
• Storage Class Code: 5.2 - Organic peroxides and self-reacting hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable