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About This Item
Empirical Formula (Hill Notation):
C4H7F2N · HCl
CAS Number:
Molecular Weight:
143.56
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.
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Quality Level
Assay
97%
form
solid
mp
133-136 °C
functional group
fluoro
SMILES string
Cl.FC1(F)CCNC1
InChI
1S/C4H7F2N.ClH/c5-4(6)1-2-7-3-4;/h7H,1-3H2;1H
InChI key
YYVPZQADFREIFR-UHFFFAOYSA-N
Application
3,3-Difluoropyrrolidine hydrochloride can be used as a building block in the synthesis of:
It can be also used as a reactant in the preparation of cyclic and acyclic β-aminofluoroalkenes via allylic amination using the Pd catalyst.[3]
- Triazole substituted prolyl difluoropyrrolidines as potential inhibitors of dipeptidyl peptidase-4.[1]
- Dual leucine zipper kinase (DLK) inhibitors.[2]
It can be also used as a reactant in the preparation of cyclic and acyclic β-aminofluoroalkenes via allylic amination using the Pd catalyst.[3]
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Activation of Allylic C-F bonds: Palladium-Catalyzed Allylic Amination of 3, 3-Difluoropropenes
Pigeon X, et al.
Angewandte Chemie (International Edition in English), 49(6), 1123-1127 (2010)
Design, Synthesis, Structure-Activity Relationships, and Docking Studies of 1-(?-1, 2, 3-Triazol Substituted Prolyl)-(S)-3, 3-Difluoropyrrolidines as a Novel Series of Potent and Selective Dipeptidyl Peptidase-4 Inhibitors
Zhang L, et al.
Chemical Biology & Drug Design, 81(2), 198-207 (2013)
Snahel Patel et al.
Journal of medicinal chemistry, 58(1), 401-418 (2014-10-24)
Dual leucine zipper kinase (DLK, MAP3K12) was recently identified as an essential regulator of neuronal degeneration in multiple contexts. Here we describe the generation of potent and selective DLK inhibitors starting from a high-throughput screening hit. Using proposed hinge-binding interactions
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