358819

Dimethyl trimethylsilyl phosphite

95%

• Synonym(s): Trimethylsilyl dimethyl phosphite
• Linear Formula: (CH₃)₃SiOP(OCH₃)₂
• CAS Number: 36198-87-5
• Molecular Weight: 182.23
• Beilstein: 1849308
• EC Number: 252-908-3
• MDL number: MFCD00075439
• UNSPSC Code: 12352100
• PubChem Substance ID: 24862029
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: 95%
• form: liquid
• refractive index: n20/D 1.410 (lit.)
• bp: 36-37 °C/11 mmHg (lit.)
• density: 0.954 g/mL at 25 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: COP(OC)O[Si](C)(C)C
• InChI: 1S/C5H15O3PSi/c1-6-9(7-2)8-10(3,4)5/h1-5H3
• InChI key: HWMXPTIFAGBDIK-UHFFFAOYSA-N

Description

Application

Dimethyl trimethylsilyl phosphite may be used in the preparation of:

• protected phosphoamino acid, Fmoc-Abu(PO₃Me₂)-OH, used in Fmoc/solid-phase peptide synthesis
• phosphoenolpyruvate (PEP) via trimethylsilylation, bromination and Perkow reaction
• sialyl phosphonate
• sulfonamide phosphonates

Safety Information

• Pictograms: GHS02,GHS05
• Signal Word: Danger
• Hazard Statements: H226,H314
• Precautionary Statements: P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Flam. Liq. 3 - Skin Corr. 1B
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 89.6 °F - closed cup
• Flash Point(C): 32 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves