33737

Dibenzyl N,N-dimethylphosphoramidite

• Empirical Formula (Hill Notation): C₁₆H₂₀NO₂P
• CAS Number: 164654-49-3
• Molecular Weight: 289.31
• Beilstein: 7427974
• MDL number: MFCD00239442
• UNSPSC Code: 12352100
• PubChem Substance ID: 57648908
• NACRES: NA.22

Properties

• refractive index: n20/D 1.553
• density: 1.089 g/mL at 20 °C (lit.)
• functional group: amine; phenyl
• storage temp.: 2-8°C
• SMILES string: CN(C)P(OCc1ccccc1)OCc2ccccc2
• InChI: 1S/C16H20NO2P/c1-17(2)20(18-13-15-9-5-3-6-10-15)19-14-16-11-7-4-8-12-16/h3-12H,13-14H2,1-2H3
• InChI key: GDEJGFHRPXLQNN-UHFFFAOYSA-N

Description

Application

Dibenzyl N,N-dimethylphosphoramidite was used in the preparation of dibenzyl phosphoramidates incorporating the representative C-terminal protected amino acids leucine, phenylalanine, glutamic acid and proline. It was also used for the fast and clean phosphitylation of alcohols, including hindered alcohols.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves