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270792

Sigma-Aldrich

4-(Chloromethyl)benzoic acid

95%

Synonym(s):

α-Chloro-p-toluic acid, α-Chloro-p-toluylic acid

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About This Item

Empirical Formula (Hill Notation):
C8H7ClO2
CAS Number:
1642-81-5
Molecular Weight:
170.59
Beilstein:
1907970
EC Number:
216-697-1
MDL number:
MFCD00002568
UNSPSC Code:
12352100
PubChem Substance ID:
24856400
NACRES:
NA.22

Assay

95%

form

powder

mp

201-202 °C (lit.)

functional group

carboxylic acid

SMILES string

OC(=O)c1ccc(CCl)cc1

InChI

1S/C8H7ClO2/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4H,5H2,(H,10,11)

InChI key

OITNBJHJJGMFBN-UHFFFAOYSA-N

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Application

4-(Chloromethyl)benzoic acid was used in the synthesis of dihydroxy stilbene derivatives.

Pictograms

Health hazardCorrosion
GHS08,GHS05

Signal Word

Danger

Hazard Statements

H314,H334

Hazard Classifications

Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sheng Yan et al.
Colloids and surfaces. B, Biointerfaces, 188, 110769-110769 (2020-01-10)
Polysulfone (PSf) membrane is widely employed in blood purification fields, but the blood compatibility of PSf membrane is not adequate. To improve the hemocompatibility of PSf membrane, 4-(chloromethyl)benzoic acid (CMBA) and sulfonated hydroxypropyl chitosan (SHPCS) were grafted onto PSf membrane
Marcela Silva Lopes et al.
Anti-cancer agents in medicinal chemistry, 15(2), 206-216 (2014-11-19)
Twenty-seven nitrated and non-nitrated compounds have been synthesized and tested for their growth inhibitory activity on three human cancer cells lines. Fourteen compounds were able to inhibit more than 50% of the growth of at least one of the cancer
Mankil Jung et al.
Bioorganic & medicinal chemistry letters, 17(16), 4481-4486 (2007-06-29)
Dihydroxy stilbene derivatives were designed based on lithospermic acid B and were prepared from 4-(chloromethyl)benzoic acid. The inhibitory activities of the novel compounds against protein tyrosine phosphatase 1B (PTP1B) were evaluated. 3,4-Dihydroxy stilbene carbonyl compounds (7, 11b, 27b) inhibited PTP1B
Yasuo Yoshimi et al.
Analytica chimica acta, 862, 77-85 (2015-02-16)
In this work, the anodic current at an electrode grafted with a molecularly imprinted polymer (MIP) crosslinked via a combination of hydrophobic ethyleneglycol dimethacrylate (EDMA) and hydrophilic methylene bisacrylamide (MBAA) was found to exhibit enantioselective sensitivity to the phenylalanine template

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