252557

4-Hydroxy-2-butanone

95%

• Synonym(s): 2-Hydroxyethyl methyl ketone
• Linear Formula: HOCH₂CH₂COCH₃
• CAS Number: 590-90-9
• Molecular Weight: 88.11
• EC Number: 209-693-6
• MDL number: MFCD00059005
• UNSPSC Code: 12352100
• PubChem Substance ID: 24855219
• NACRES: NA.22

Properties

• Assay: 95%
• refractive index: n20/D 1.430 (lit.)
• bp: 73-76 °C/12 mmHg (lit.)
• density: 1.023 g/mL at 25 °C (lit.)
• functional group: hydroxyl; ketone
• SMILES string: CC(=O)CCO
• InChI: 1S/C4H8O2/c1-4(6)2-3-5/h5H,2-3H2,1H3
• InChI key: LVSQXDHWDCMMRJ-UHFFFAOYSA-N

Description

General description

4-Hydroxy-2-butanone is a beta-hydroxy ketone used as a starting material to synthesize 1,3-butanediol.

4-Hydroxy-2-butanone is an important pharmaceutical intermediate. Gas phase reaction of the OH radicals with 4-hydroxy-2-butanone has been investigated by absolute rate method.

Application

4-Hydroxy-2-butanone has been used in the synthesis of:

• 3-buten-2-one via dehydration over anatase-TiO₂ catalyst
• 4-methyl-5-hydroxymethylthiazole
• (±)-lineatin
• mevalonic acid lactone
• verrucarin
• β-hydroxylactones

Safety Information

• Pictograms: GHS02
• Signal Word: Warning
• Hazard Statements: H226
• Hazard Classifications: Flam. Liq. 3
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 91.4 °F - closed cup
• Flash Point(C): 33 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves