Skip to Content
Merck
All Photos(4)

Documents

N4875

Sigma-Aldrich

Naphthol AS-MX phosphate

phosphatase substrate, fluorogenic, ≥99% (HPLC), powder

Synonym(s):

3-Hydroxy-2-naphtho-2′,4′-xylidide Phosphate, N-(2,4-Dimethylphenyl)-3-(phosphonooxy)-2-naphthalenecarboxamide

Sign Into View Organizational & Contract Pricing
All Photos(4)

About This Item

Empirical Formula (Hill Notation):
C19H18NO5P
CAS Number:
1596-56-1
Molecular Weight:
371.32
Beilstein:
6664873
EC Number:
216-480-1
MDL number:
MFCD00042711
UNSPSC Code:
12352204
PubChem Substance ID:
24897714
NACRES:
NA.83

product name

Naphthol AS-MX phosphate, powder, ≥99% (HPLC)

Assay

≥99% (HPLC)

form

powder

solubility

ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow (to Faint Brown)

storage temp.

−20°C

SMILES string

Cc1ccc(NC(=O)c2cc3ccccc3cc2OP(O)(O)=O)c(C)c1

InChI

1S/C19H18NO5P/c1-12-7-8-17(13(2)9-12)20-19(21)16-10-14-5-3-4-6-15(14)11-18(16)25-26(22,23)24/h3-11H,1-2H3,(H,20,21)(H2,22,23,24)

InChI key

IOMLBTHPCVDRHM-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Naphthol AS-MX phosphate is soluble in dioxane and is a substrate for phosphatase.

Application

Naphthol AS-MX phosphate has been used as:
  • a substrate for alkaline phosphatase in human osteoblasts
  • mouse embryonic stem cell (mESC)
  • coronal plane sections for fluorescence staining and analysis

Substrate for the histochemical demonstration of alkaline phosphatase.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 1

1 of 1

Leukocyte Alkaline Phosphatase Kit based on naphthol AS-MX phosphate and fast blue RR salt

Sigma-Aldrich

85L1

Leukocyte Alkaline Phosphatase Kit

Effects of an injectable platelet-rich fibrin on osteoblast behavior and bone tissue formation in comparison to platelet-rich plasma
Wang X, et al.
Platelets, 29(1), 48-55 (2018)
Developmental-like bone regeneration by human embryonic stem cell-derived mesenchymal cells.
Kuhn LT, Liu Y, Boyd NL, et al.
Tissue Engineering: Part A, 20(1-2), 365-377 (2014)
Fluorescence of Naphthol AS-MX is Readily Detectable in Dioxane Mixtures
Kindl ED, et al.
Matters, 5(5), e201905000003-e201905000003 (2019)
Nanofiber/Microsphere Hybrid Matrices In Vivo for Bone Regenerative Engineering: A Preliminary Report
Nelson C, et al.
Regenerative engineering and translational medicine, 4(3), 133-141 (2018)
Mitsuhiro Kinoshita et al.
Scientific reports, 11(1), 20360-20360 (2021-10-15)
Nephronectin (Npnt) is an extracellular matrix protein and ligand of integrin α8β1 known to promote differentiation of osteoblasts. A search for factors that regulate Npnt gene expression in osteoblasts revealed that phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service