Skip to Content
Merck
All Photos(2)

Documents

N4396

Sigma-Aldrich

Nalbuphine hydrochloride hydrate

≥98% (HPLC), powder, μ and κ opioid receptors agonist

Synonym(s):

17-(Cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol hydrochloride hydrate

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Empirical Formula (Hill Notation):
C21H27NO4 · HCl · xH2O
CAS Number:
23277-43-2
Molecular Weight:
393.90 (anhydrous basis)
EC Number:
245-549-9
UNSPSC Code:
12352200
PubChem Substance ID:
24278052
NACRES:
NA.77

product name

Nalbuphine hydrochloride hydrate, ≥98% (HPLC)

Assay

≥98% (HPLC)

form

powder

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

solubility

H2O: soluble
ethanol: soluble

originator

Abbott

SMILES string

Cl[H].[H]O[H].[H][C@@]12Oc3c(O)ccc4C[C@H]5N(CC[C@@]1(c34)[C@@]5(O)CC[C@@H]2O)CC6CCC6

InChI

1S/C21H27NO4.ClH.H2O/c23-14-5-4-13-10-16-21(25)7-6-15(24)19-20(21,17(13)18(14)26-19)8-9-22(16)11-12-2-1-3-12;;/h4-5,12,15-16,19,23-25H,1-3,6-11H2;1H;1H2/t15-,16+,19-,20-,21+;;/m0../s1

InChI key

IUGXDRGXUYNFHK-XSFMULHUSA-N

Gene Information

human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988)

General description

Nalbuphine functions as an analgesic. It has anti catabolic properties. Nalbuphine maybe associated with sedation, nausea and vomiting.

Biochem/physiol Actions

Partial agonist for μ and κ opioid receptors.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300 + H310 + H330

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

L R Gerak et al.
The Journal of pharmacology and experimental therapeutics, 276(2), 523-531 (1996-02-01)
Three rhesus monkeys discriminated between 0.178 mg/kg of nalbuphine and saline while responding under a fixed-ratio 5 schedule of stimulus-shock termination. Nalbuphine produced dose-related increases in drug-lever responding with > or = 90% of responses occurring on the drug lever
P J Emmerson et al.
Journal of neurochemistry, 73(1), 289-300 (1999-07-01)
The influence of membrane microviscosity on mu-opioid agonist and antagonist binding, as well as agonist efficacy, was examined in membranes prepared from SH-SY5Y cells and from a C6 glioma cell line stably expressing the rat mu-opioid receptor (C6mu). Addition of
Nalbuphine
Schmidt WK, et al.
Drug and Alcohol Dependence, 14(3-4), 339-362 (1985)
Three cases of nalbuphine hydrochloride dependence associated with anabolic steroid use.
McBride AJ, et al.
British Journal of Sports Medicine, 30(1), 69-70 (1996)
Evaluation of nalbuphine hydrochloride
Miller RR
American Journal of Health-System Pharmacy, 37(7), 942-949 (1980)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service