BCR312
2-Nitro-7-methoxynaphtho[2,1-b]furan
BCR®, certified reference material
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About This Item
Empirical Formula (Hill Notation):
C13H9NO4
CAS Number:
Molecular Weight:
243.21
Beilstein:
5749492
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
grade
certified reference material
Agency
BCR®
manufacturer/tradename
JRC
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
format
neat
storage temp.
2-8°C
SMILES string
COc1ccc2c(ccc3oc(cc23)[N+]([O-])=O)c1
InChI
1S/C13H9NO4/c1-17-9-3-4-10-8(6-9)2-5-12-11(10)7-13(18-12)14(15)16/h2-7H,1H3
InChI key
BRRIJZQYTOFDAF-UHFFFAOYSA-N
Analysis Note
For more information please see:
BCR312
BCR312
Legal Information
BCR is a registered trademark of European Commission
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Muta. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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R J Salmon et al.
Carcinogenesis, 10(5), 803-805 (1989-05-01)
2-Nitro-oxaphenalenes are synthetic chemicals which were synthesized in the authors' laboratory. They are the most efficient mutagenic compounds on mammalian cells in culture. They are chemically related to the nitro-naphthofuran family by the displacement of the heterocycle on the naphthalene
D Le François-Chabas et al.
Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie, 296(6), 283-286 (1983-01-01)
We have studied the in vitro malignant progression of human lymphoid cells by the combined effect of genetic, viral and mutagenic factors. A lymphoblastoid cell line immortalized by Epstein-Barr virus was used; it was derived from a patient suffering from
J C Maurizis et al.
Xenobiotica; the fate of foreign compounds in biological systems, 15(2), 141-148 (1985-02-01)
The disposition of 7-methoxy-2-nitronaphtho[2,1-b]furan (MNNF), labelled with 14C in the furan ring (label 1) and in the methoxy group (label 2) has been studied in rats and mice. After i.p. administration to rat (5 mg/kg), both labelled species were absorbed
E Touati et al.
Mutation research, 349(2), 193-200 (1996-02-01)
We have studied the global changes which are induced in exponentially growing cultures of Escherichia coli during treatment with 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000), a very potent mutagen and inducer of the SOS response. A two-dimensional analysis of the proteins synthesized in the
L Cui et al.
Cancer letters, 76(2-3), 161-166 (1994-01-30)
Among the nitro-naphthofurans, 7-methoxy-2-nitro-naphtho[2,1-b]furan (R7000) has proved to be a very potent mutagen that causes sarcomas at the subcutaneous injection site and carcinomas in the forestomach after p.o. administration. In the present study, possible promoting activity for diethylnitrosamine (200 mg/kg
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