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Merck

AB3607

Sigma-Aldrich

Anti-ASC Antibody

Chemicon®, from rabbit

Synonym(s):

TMS1, CARD5, Apoptosis-associated Speck-like Protein containing a CARD

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Pricing and availability is not currently available.

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

western blot: suitable

UniProt accession no.

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This Item
2353851162519670
Quality Level

200

Quality Level

-

Quality Level

200

Quality Level

-

solubility

alcohol: very soluble, diethyl ether: very soluble, water: slightly soluble, chloroform: very soluble, glycerol: insoluble

solubility

alcohol: very soluble(lit.), carbon disulfide: very soluble(lit.), chloroform: very soluble(lit.), diethyl ether: very soluble(lit.), glycerol: insoluble (practically)(lit.), water: slightly soluble(lit.)

solubility

-

solubility

methanol: soluble 1 g/10 mL, clear, colorless to slightly yellow

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

bp

61-63 °C (lit.)

bp

61-63 °C (lit.)

bp

-

bp

285 °C (lit.)

refractive index

n20/D 1.368 (lit.)

refractive index

n20/D 1.368 (lit.)

refractive index

-

refractive index

-

General description

Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, Bcl10, Apaf-1, ARC, caspase-2 and caspase-9. A novel CARD domain containing protein has been identified in human and mouse and designated ASC and TMS1. Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells. Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues.

Specificity

Detects a 25 kDa band by western blot, corresponding to ASC/TMS1.

Immunogen

Peptide corresponding to aa 182-195 (RESQSYLVEDLERS) of human ASC.

Application

Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
This Anti-ASC Antibody is validated for use in WB for the detection of ASC.
Western blot: 1:500

HL60 whole cell lysate can be used as a positive control.

Optimal working dilutions must be determined by end user.

Physical form

Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.
Format: Purified

Storage and Stability

Maintain at 4°C for up to 6 months.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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