SML3923

NU7441

≥98% (HPLC)

• Synonym(s): 8-Dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one, NU 7441, NU-7441
• Empirical Formula (Hill Notation): C₂₅H₁₉NO₃S
• CAS Number: 503468-95-9
• Molecular Weight: 413.49
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD11983069
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: 2-8°C
• SMILES string: [s]1c2c(c6c1cccc6)cccc2c3c4[o]c(c[c](c4ccc3)=O)N5CCOCC5
• InChI: 1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2
• InChI key: JAMULYFATHSZJM-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor in vitro and in vivo.
NU7441 is a potent and selective DNA-dependent protein kinase inhibitor (DNA-PK IC50 = 14 nM; IC50 = 1.7 μM/mTOR, 5 μM/PI3Kα, >100 μM/ATM & ATR) that effectively sensitizes cancer cells to the cytotoxic effects of both ionizing radiation and the topoisomerase II inhibitor etoposide in cultures (0.5 μM; SW620 & LoVo cells) and in vivo (10 mg/kg via daily i.p. in mice with human colon cancer SW620 xenografts).

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable