Unfortunately, the iodide form of this compound is the only product option available at this time.
SML2832
5-Amino-1-methylquinolinium iodide
≥98% (HPLC)
Synonym(s):
5-Amino-1-MQ iodide, 5-Amino-1-methylquinolinium, iodide (1:1), 5-Amino-1MQ iodide
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About This Item
Empirical Formula (Hill Notation):
C10H11N2·I
CAS Number:
Molecular Weight:
286.11
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Quality Segment
assay
≥98% (HPLC)
form
powder
color
faint red to dark brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
C[N+]1=CC=CC2=C(C=CC=C12)N.[I-]
InChI
1S/C10H10N2.HI/c1-12-7-3-4-8-9(11)5-2-6-10(8)12;/h2-7,11H,1H3;1H
InChI key
JPEZFBFIRRAFNR-UHFFFAOYSA-N
Biochem/physiol Actions
5-Amino-1-methylquinolinium (5-amino-1MQ) is a substrate site-targeting, selective nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM; 50 μM SAM, 100 μM NCA) that reduces 3T3-L1 lipogenesis (EC50 = 30μM) and adipocytes 1-methylnicotinamide level (EC50 = 2.3 μM) without affecting related methyltransferases & enzymes in the NAD+ salvage pathway. 5-amino-1MQ shows in vivo therapeutic efficacy in murine models of DIO (20 mg/kg/d sc.), muscle injury (5 or 10 mg/kg bid. sc.), and intraperitoneal HeyA8 ovarian cancer metastasis (20 mg/kg/d ip.) with no adverse effects to the animals (up to 60 mg/kg/d). Note:1.89 mg iodide salt contains 1 mg eq of 5-amino-1MQ.
Substrate site-targeting, selective nicotinamide N-methyltransferase (NNMT) inhibitor with in vitro and in vivo efficay.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description >97% (HPLC) | description ≥98% (HPLC), powder | description Dye content 95 % |
| form powder | form powder | form powder | form powder or crystals |
| assay ≥98% (HPLC) | assay >97% (HPLC) | assay ≥98% (HPLC) | assay - |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level 200 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. - | storage temp. room temp |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility H2O: 10 mg/mL, clear | solubility ethanol: 1 mg/mL, clear, dark red |
| color faint red to dark brown | color white to beige | color white to beige | color - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Can there be a chloride salt version that is white?
1 answer-
Helpful?
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Does 5 amino 1MQ have iodine in it?
1 answer-
Yes, iodine is present as this product is the iodide salt of 5-Amino-1MQ . This is not a covalent bond and the Iodine will ionize in solution. Please see the link below to review a sample Certificate of Analysis:
https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/SML2832-5MG0000102634.pdfHelpful?
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